Molecular profile in endometrial carcinoma: can we predict the lymph node status? A systematic review and meta-analysis.
Clin Transl Oncol
; 26(7): 1768-1778, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38578538
ABSTRACT
PURPOSE:
Molecular classification of endometrial cancer (EC) has become a promising information to tailor preoperatively the surgical treatment. We aimed to evaluate the rate of lymph node metastases (LNM) in patients with EC according to molecular profile.METHODS:
A systematic review and meta-analysis were performed according to PRISMA guidelines by searching in two major electronic databases (PubMed and Scopus), including original articles reporting lymph node metastases according to the molecular classification of EC as categorized in the ESGO-ESMO-ESP guidelines.RESULTS:
Fifteen studies enrolling 3056 patients were included. Pooled prevalence LNM when considering only patients undergoing lymph node assessment was 4% for POLE-mutated (95%CI 0-12%), 22% for no specific molecular profile (95% CI 9-39%), 23% for Mismatch repair-deficiency (95%CI 10-40%) and 31% for p53-abnormal (95%CI 24-39%).CONCLUSIONS:
The presence of LNM seems to be influenced by molecular classification. P53-abnormal group presents the highest rate of nodal involvement, and POLE-mutated the lowest.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Endométrio
/
Metástase Linfática
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Itália