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Metabolites and Cognitive Decline in a Puerto Rican Cohort.
Gordon, Scott; Lee, Jong Soo; Scott, Tammy M; Bhupathiraju, Shilpa; Ordovas, Jose; Kelly, Rachel S; Tucker, Katherine L; Palacios, Natalia.
Afiliação
  • Gordon S; Department of Computer Science, University of Massachusetts Lowell, Lowell, MA, USA.
  • Lee JS; Department of Mathematical Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
  • Scott TM; Center for Population Health, University of Massachusetts Lowell, Lowell, MA, USA.
  • Bhupathiraju S; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  • Ordovas J; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
  • Kelly RS; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Tucker KL; Jean Mayer USDA Human Research Center on Aging, Tufts University, Boston, MA, USA.
  • Palacios N; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
J Alzheimers Dis ; 99(s2): S345-S353, 2024.
Article em En | MEDLINE | ID: mdl-38578885
ABSTRACT

Background:

Recent studies have identified plasma metabolites associated with cognitive decline and Alzheimer's disease; however, little research on this topic has been conducted in Latinos, especially Puerto Ricans.

Objective:

This study aims to add to the growing body of metabolomics research in Latinos to better understand and improve the health of this population.

Methods:

We assessed the association between plasma metabolites and global cognition over 12 years of follow-up in 736 participants of the Boston Puerto Rican Health Study (BPRHS). Metabolites were measured with untargeted metabolomic profiling (Metabolon, Inc) at baseline. We used covariable adjusted linear mixed models (LMM) with a metabolite * time interaction term to identify metabolites (of 621 measured) associated with ∼12 years cognitive trajectory.

Results:

We observed strong inverse associations between medium-chain fatty acids, caproic acid, and the dicarboxylic acids, azelaic and sebacic acid, and global cognition. N-formylphenylalanine, a tyrosine pathway metabolite, was associated with improvement in cognitive trajectory.

Conclusions:

The metabolites identified in this study are generally consistent with prior literature and highlight a role medium chain fatty acid and tyrosine metabolism in cognitive decline.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hispânico ou Latino / Metabolômica / Disfunção Cognitiva Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Caribe / Puerto rico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hispânico ou Latino / Metabolômica / Disfunção Cognitiva Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Caribe / Puerto rico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda