Your browser doesn't support javascript.
loading
Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study.
Nobre, Daniel Augusto Barnabé; Moura, Mariela Dutra Gontijo; de Arruda, José Alcides Almeida; Felix, Fernanda Aragão; Diniz, Priscilla Barbosa; Duarte, Eliza Carla Barroso; Abreu, Lucas Guimarães; Gomez, Ricardo Santiago; Mesquita, Ricardo Alves.
Afiliação
  • Nobre DAB; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Moura MDG; Department of Dentistry, Centro Universitário Vale do Rio Verde - UNINCOR, Belo Horizonte, Brazil.
  • de Arruda JAA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Felix FA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Diniz PB; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Duarte ECB; Department of Pathology, School of Medicine, Universidade de Brasília, Brasília, Brazil.
  • Abreu LG; Department of Child and Adolescent Oral Health, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Gomez RS; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Mesquita RA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Int J STD AIDS ; 35(8): 627-634, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38606785
ABSTRACT

BACKGROUND:

This study evaluated the presence of Epstein-Barr virus type 1 (EBV-1) DNA in patients living with HIV, before and after three different topical therapy protocols for oral hairy leukoplakia (OHL).

METHODS:

The sample consisted of five patients treated with topical solution of 25% podophyllin resin; six with 25% podophyllin resin plus 5% acyclovir cream; and four with 25% podophyllin resin plus 1% penciclovir cream. DNA was extracted from OHL scrapings and amplified by the PCR using specific primers for EBV-1 (EBNA-1).

RESULTS:

Clinical healing of OHL lesions was observed across all treatment groups over time. At baseline, EBNA-1 was detected in all OHL lesions. After treatment, OHL samples from three patients treated with 25% podophyllin resin plus 5% acyclovir cream and from one patient treated with 25% podophyllin resin plus 1% penciclovir cream exhibited negative EBNA-1 viral gene encoding. Despite the clinical resolution of OHL, 11 patients (73.3%) showed EBNA-1 positivity immediately after the lesion disappeared. Three patients (20%) treated with podophyllin resin displayed both EBNA-1 positivity and a recurrence of OHL, in contrast to no recurrence in the other two groups.

CONCLUSIONS:

These findings suggest potential associations between treatment formulations, EBNA-1 persistence, and the recurrence of OHL lesions.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Aciclovir / DNA Viral / Administração Tópica / Leucoplasia Pilosa / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J STD AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Aciclovir / DNA Viral / Administração Tópica / Leucoplasia Pilosa / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J STD AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido