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Effects of cancer-induced cachexia and administration of L-glutathione on the intestinal mucosa in rat.
Sestak, Sabrina Silva; da Motta Lima, Fabiana Galvão; de Oliveira, Ana Paula; Barateiro, Letícia Ganem Rillo Paz; Vieira-Frez, Flávia Cristina; de Souza, Sara Raquel Garcia; Guarnier, Flávia Alessandra; Perles, Juliana Vanessa Colombo Martins; Zanoni, Jacqueline Nelisis.
Afiliação
  • Sestak SS; Department of Physiology, Laboratory of Enteric Neural Plasticity, State University of Maringá, O33 Block, Colombo Avenue, 5790, Maringá, Paraná, CEP 87020-900, Brazil.
  • da Motta Lima FG; Department of Physiology, Laboratory of Enteric Neural Plasticity, State University of Maringá, O33 Block, Colombo Avenue, 5790, Maringá, Paraná, CEP 87020-900, Brazil.
  • de Oliveira AP; Department of Physiology, Laboratory of Enteric Neural Plasticity, State University of Maringá, O33 Block, Colombo Avenue, 5790, Maringá, Paraná, CEP 87020-900, Brazil.
  • Barateiro LGRP; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
  • Vieira-Frez FC; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
  • de Souza SRG; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
  • Guarnier FA; Department of Pathology Sciences, State University of Londrina, Londrina, Paraná, Brazil.
  • Perles JVCM; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
  • Zanoni JN; Department of Physiology, Laboratory of Enteric Neural Plasticity, State University of Maringá, O33 Block, Colombo Avenue, 5790, Maringá, Paraná, CEP 87020-900, Brazil. jnzanoni@uem.br.
Amino Acids ; 56(1): 30, 2024 Apr 12.
Article em En | MEDLINE | ID: mdl-38607556
ABSTRACT
Walker-256 tumor is an experimental model known to promote cachexia syndrome, oxidative stress, and systemic inflammation. This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% L-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups control (C); control administered with 1% L-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% L-glutathione (W-GSH). After 14 days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immunostaining of varicosities immunoreactive (IR) to vasoactive intestinal peptide (VIP) and 5-HT-IR cells, and quantification of mast cells and goblet cells. Walker-256 tumor-bearing rats showed cachexia syndrome, mucosal atrophy, reduced cell proliferation, reduced 5-HT-IR cells, and increased goblet cells and VIPergic varicosities, which were not reversed by L-glutathione. On the other hand, L-glutathione caused a reduction of cells in apoptosis and mast cell recruitment, demonstrating a partial recovery of the damage detected in the intestinal mucosa.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caquexia / Neoplasias Limite: Animals Idioma: En Revista: Amino Acids Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caquexia / Neoplasias Limite: Animals Idioma: En Revista: Amino Acids Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria