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Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study.
Sun, Keming; Zhang, Chunxu; Mao, Ziwen; Wang, Chen; Zhu, Hua; Sun, Huiqing; Wang, Kang; Cheng, Weyland.
Afiliação
  • Sun K; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Department of Orthopaedic Surgery, Zhengzhou, Henan, China.
  • Zhang C; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Department of Orthopaedic Surgery, Zhengzhou, Henan, China.
  • Mao Z; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Department of Orthopaedic Surgery, Zhengzhou, Henan, China; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan Provin
  • Wang C; Hebei Children's Hospital, Department of Orthopaedic Surgery, Shijiazhuang, Hebei, China.
  • Zhu H; Hebei Children's Hospital, Department of Orthopaedic Surgery, Shijiazhuang, Hebei, China.
  • Sun H; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Department of Neonatology, Zhengzhou, Henan, China.
  • Wang K; Hebei Children's Hospital, Department of Orthopaedic Surgery, Shijiazhuang, Hebei, China.
  • Cheng W; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Department of Orthopaedic Surgery, Zhengzhou, Henan, China; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan Provin
J Pediatr (Rio J) ; 100(4): 430-437, 2024.
Article em En | MEDLINE | ID: mdl-38642591
ABSTRACT

OBJECTIVE:

Signs and symptoms of osteomyelitis or septic arthritis in neonates and infants are often nonspecific and early-stage bone infections in infants may often go unnoticed. The objective of this study was to analyze the clinical characteristics of newborns and infants with osteomyelitis and septic arthritis to improve understanding of the disorder and to assist clinicians with diagnosis.

METHODS:

A retrospective multicenter study was conducted on neonates (0-28 days old, n = 94) and infants (1-12 months old, n = 415) with osteoarticular infections. Data consisting of clinical characteristics, complications, laboratory outcomes, and the pathogenic microorganisms causing osteomyelitis were tabulated. The statistics were further broken down into two regions and the significant differences between neonates and infants were evaluated and compared to the literature.

RESULTS:

Compared to infants, neonates had significantly lower incidences of fever (p < 0.0001), higher incidences of localized swelling (p = 0.0021), higher rate of infection at the humerus (p = 0.0016), higher percentage of Escherichia coli (p < 0.0001) and Klebsiella pneumoniae (p = 0.0039) infections, lower percentage of Staphylococcus aureus infections (p < 0.0001) and were more likely to develop septic arthritis (p < 0.0001).

CONCLUSION:

Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Artrite Infecciosa Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Artrite Infecciosa Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Brasil