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A Case Study of a Rare Undifferentiated Spindle Cell Sarcoma of the Penis: Establishment and Characterization of Patient-Derived Models.
Sousa, Ariane Cavalcante Dos Santos; Fernandes, Bruno Leonardo Nascimento Correa; da Silva, Jeronimo Paulo Assis; Stevanato Filho, Paulo Roberto; Coimbra, Luiza Bitencourt de Carvalho Terci; de Oliveira Beserra, Adriano; Alvarenga, Ana Luiza; Maida, Giovanna; Guimaraes, Camila Tokumoto; Nakamuta, Ingrid Martinez; Marchi, Fabio Albuquerque; Alves, Camila; Lichtenfels, Martina; de Farias, Caroline Brunetto; Kupper, Bruna Elisa Catin; Costa, Felipe D'Almeida; de Mello, Celso Abdon Lopes; Carraro, Dirce Maria; Torrezan, Giovana Tardin; Lopes, Ademar; Dos Santos, Tiago Goss.
Afiliação
  • Sousa ACDS; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • Fernandes BLNC; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • da Silva JPA; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil.
  • Stevanato Filho PR; Sao Lucas Hospital Rede D'Or, Sergipe Emergency Hospital Oncology Service, Aracaju 49081-060, Brazil.
  • Coimbra LBCT; Real Institute of Oncological Surgery, Real Hospital Português, Recife 52010-075, Brazil.
  • de Oliveira Beserra A; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.
  • Alvarenga AL; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • Maida G; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • Guimaraes CT; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • Nakamuta IM; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • Marchi FA; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil.
  • Alves C; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • Lichtenfels M; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • de Farias CB; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • Kupper BEC; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • Costa FD; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
  • de Mello CAL; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.
  • Carraro DM; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil.
  • Torrezan GT; Heart Institute of School of Medicine, University of Sao Paulo, Sao Paulo 05403-900, Brazil.
  • Lopes A; Center for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo (ICESP), Clinical Hospital of the University of Sao Paulo Medical School (HCFMUSP), Sao Paulo 01246-000, Brazil.
  • Dos Santos TG; Ziel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil.
Genes (Basel) ; 15(4)2024 03 28.
Article em En | MEDLINE | ID: mdl-38674359
ABSTRACT
Rare sarcomas present significant treatment challenges compared to more prevalent soft tissue sarcomas due to limited treatment options and a poor understanding of their biology. This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models-including patient-derived xenograft (PDX), 3D, and monolayer primary cultures-we successfully replicated crucial molecular traits observed in the patient's tumor, such as smooth muscle actin and CD99 expression, along with specific mutations in genes like TSC2 and FGFR4. These models are helpful in assessing the potential for an in-depth exploration of this tumor's biology. This comprehensive approach holds promise in identifying potential therapeutic avenues for managing this exceedingly rare soft tissue sarcoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma Limite: Animals / Humans / Male / Middle aged Idioma: En Revista: Genes (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma Limite: Animals / Humans / Male / Middle aged Idioma: En Revista: Genes (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça