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Alteration in the Expression of Circular Rnas and its association with the Development and Progression of Osteosarcoma, an Integrative Review with High Sensitivity Research.
Lima, Felipe Alves De; Fernandes, Fernando Liberalino; Almeida, Daria Raquel Queiroz De; Carvalho, Amanda Estevam; Almeida, Valéria Duarte; Cavalcante, Gilson Aquino; Morais, Nickson Melo De; Rodrigues, Tayline Dantas; Nascimento, Ellany Gurgel Cosme Do; Fonseca, Ivana Alice Teixeira; Bezerra, Christiane Medeiros; Fernandes, Jose Verissimo; Fernandes, Thales Thales Allyrio Araujo De Medeiros.
Afiliação
  • Lima FA; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Fernandes FL; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Almeida DRQ; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Carvalho AE; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Almeida VD; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Cavalcante GA; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Morais NM; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Rodrigues TD; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Nascimento EGCD; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Fonseca IAT; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
  • Bezerra CM; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Fernandes JV; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Fernandes TTAAM; Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Asian Pac J Cancer Prev ; 25(4): 1195-1203, 2024 04 01.
Article em En | MEDLINE | ID: mdl-38679978
ABSTRACT

BACKGROUND:

Osteosarcoma is the most common primary malignant bone tumor, mainly affecting children, young adults, and the elderly. It is an aggressive cancer with a poor prognosis, exhibiting low survival rates even with standard treatment. Recently, circular RNA molecules capable of influencing gene expression through various functions, with their main role being acting as microRNA sponges and reducing their intracellular expression, have been identified. Recent studies have linked circular RNAs to osteosarcoma development and progression. Therefore, the present study aimed to investigate the alteration in circular RNA expression during osteosarcoma development and progression.

METHODS:

An integrative literature review was conducted from September 10th to November 12th, 2021, using the following databases PubMed/MEDLINE, SCOPUS, Web of Science, OVID, and EMBASE. 129 full articles were included in the review. The obtained data were organized using a standardized data collection instrument, which included the following information altered expression profile of circular RNAs, associated cancer hallmarks, clinical-pathological relationships of circular RNAs, and perspectives on the studied circular RNAs.

RESULTS:

A total of 94 distinct circular RNAs were identified, predominantly showing an increased expression pattern. Approximately 91% of the studies that aimed to identify the mechanisms of action of circular RNAs highlighted the function of circular RNAs as microRNA sponges. The most associated cancer hallmarks with the identified circular RNAs were proliferative signaling induction, invasion and metastasis, and resistance to cell death. The altered expression of these circular RNAs generally correlated with a worse prognosis for patients, as evidenced by clinical features such as shorter survival, advanced Enneking and/or TNM stage, higher incidence of metastasis, larger tumor size, and increased chemoresistance. CONSLUSION These findings indicate the significance of circular RNA molecules in osteosarcoma carcinogenesis, suggesting their potential as new prognostic and/or diagnostic biomarkers, as well as alternative therapeutic targets in the fight against osteosarcoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Progressão da Doença / RNA Circular Limite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Progressão da Doença / RNA Circular Limite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia