Chemoenzymatic formal synthesis of (+)-brazilin.

Liu, Jiangtao; Han, Xue; Yu, Liuping; Zhang, Jiandong; Huang, Shuangping; Yang, Xihua; Chang, Honghong

Liu, Jiangtao; Han, Xue; Yu, Liuping; Zhang, Jiandong; Huang, Shuangping; Yang, Xihua; Chang, Honghong.

Afiliação

Liu J; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Han X; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Yu L; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Zhang J; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Huang S; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Yang X; Laboratory Animal Center, Shanxi Cancer Institute, Taiyuan, China.
Chang H; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.

Nat Prod Res ; : 1-11, 2024 May 07.

Article em En | MEDLINE | ID: mdl-38712549

ABSTRACT

ABSTRACT

Herein, the manuscript presents a chemoenzymatic formal synthetic route of (+)-brazilin, a homoisoflavonoid natural product with a chroman skeleton cis-fused with a 2,3-dihydro-1H-indene unit, which is isolated from the traditional Chinese medicine, Caesalpinia sappan L. The key feature of the synthetic strategy includes an enzyme-mediated desymmetrization by employing lipase from Candida antarctica type B (CALB) and a one-pot SN2/hydrolysis reaction.

Palavras-chave

(+)-brazilin; CALB lipase; Natural product; chemoenzymatic synthesis; desymmetrization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nat Prod Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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