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Ozone therapy by rectal insufflation in dogs: safety and oxidative stress - a randomized cross-over study.
de Oliveira, Paula Lima; Mendonça, Mariana Orlandini; Gonçalves, Geovanna Santos; Franco, Isadora Gimenez; Jané, Daniela Ribas; de Oliveira Martins, Tainara; Bosculo, Maria Rachel Melo; Montechiesi, Daniela Fernandez; Zamboni, Vinicius Aquiles Gomes; Floriano, Beatriz Perez; de Almeida, Breno Fernando Martins.
Afiliação
  • de Oliveira PL; Faculty of Veterinary Medicine of Araçatuba, São Paulo State University (FMVA-Unesp), Araçatuba, São Paulo State, Brazil.
  • Mendonça MO; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • Gonçalves GS; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • Franco IG; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • Jané DR; Faculty of Veterinary Medicine of Araçatuba, São Paulo State University (FMVA-Unesp), Araçatuba, São Paulo State, Brazil.
  • de Oliveira Martins T; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • Bosculo MRM; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • Montechiesi DF; Autonomous Veterinary Doctor, Ourinhos, São Paulo State, Brazil.
  • Zamboni VAG; Faculty of Veterinary Medicine of Araçatuba, São Paulo State University (FMVA-Unesp), Araçatuba, São Paulo State, Brazil.
  • Floriano BP; Department of Veterinary Medicine, Centro Universitário das Faculdades Integradas de Ourinhos (Unifio), Ourinhos, São Paulo State, Brazil.
  • de Almeida BFM; Department of Small Animal Clinic, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil.
Vet Res Commun ; 48(4): 2263-2280, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38733456
ABSTRACT
Ozone therapy acts in the body inducing controlled oxidative stress, thereby improving the antioxidant, immune and circulatory responses. However, very little is known about how this therapy affects oxidative stress indicators in dogs. We aimed to assess the clinical, hematological, biochemical and oxidative stress parameters of healthy dogs subjected to ozone therapy and oxygen therapy by rectal insufflation. Ten healthy dogs were allocated into three experimental groups in a cross-over

design:

control, without intervention; ozone, which received 100 µg of O3/kg through rectal insufflation; and oxygen, which received an ozone-equivalent volume of medicinal O2 through rectal insufflation. Dogs received four applications weekly and were followed up until the seventh week. Ozone therapy significantly increased the weight, mean corpuscular volume and mean platelet volume and decreased total cholesterol of treated dogs. Regarding oxidative stress, ozone therapy reduced total antioxidant capacity by ferric reduction (TAC-FRAP) in D7 compared with baseline and the control, significantly increased total antioxidant capacity by cupric reduction (TAC-CUPRAC) in D42 and D49 compared with the control group, caused an increase in uric acid compared with the oxygen group and decreased lipid peroxidation on D21 compared with the control group. In conclusion, ozone therapy through rectal insufflation causes transient oxidative stress followed by an antioxidant response and discreetly interferes with a few clinical, hematological and biochemical variables in healthy dogs, although variables still remained within the reference ranges for the species, thus proving the safety of the therapy. Furthermore, oxygen therapy causes oxidative stress without inducing a subsequent antioxidant response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Reto / Insuflação / Estresse Oxidativo / Estudos Cross-Over Limite: Animals Idioma: En Revista: Vet Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Reto / Insuflação / Estresse Oxidativo / Estudos Cross-Over Limite: Animals Idioma: En Revista: Vet Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça