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Oral supplementation with resveratrol improves hormonal profile and increases expression of genes associated with thermogenesis in oophorectomy mice.
Viana, Fhelício Sampaio; Pereira, Juliana Andrade; Crespo, Thaísa Soares; Reis Amaro, Lílian Betânia; Rocha, Eliezer Francisco; Fereira, Alice Crespo; Lelis, Deborah de Farias; Baldo, Thaís de Oliveira Faria; Baldo, Marcelo Perim; Santos, Sérgio Henrique Sousa; Andrade, João Marcus Oliveira.
Afiliação
  • Viana FS; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
  • Pereira JA; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
  • Crespo TS; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil.
  • Reis Amaro LB; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
  • Rocha EF; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
  • Fereira AC; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
  • Lelis DF; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil.
  • Baldo TOF; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil.
  • Baldo MP; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil.
  • Santos SHS; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil; Graduate Program in Food and Health (Programa de Pós-Graduação em Alimentos e Saú
  • Andrade JMO; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil; Gr
Mol Cell Endocrinol ; 591: 112268, 2024 Sep 15.
Article em En | MEDLINE | ID: mdl-38735622
ABSTRACT
Menopause causes important bodily and metabolic changes, which favor the increased occurrence of cardiovascular diseases, obesity, diabetes, and osteoporosis. Resveratrol exerts proven effects on body metabolism, improving glucose and lipid homeostasis and reducing inflammation and oxidative stress in various organs and tissues. Accordingly, this study evaluates the effects of resveratrol supplementation on the expression of markers associated with thermogenesis in brown adipose tissue, and on the body, metabolic and hormonal parameters of female mice submitted to bilateral oophorectomy. Eighteen female mice were randomized into three groups G1 control (CONTROL), G2 oophorectomy (OOF), and G3 oophorectomy + resveratrol (OOF + RSV); the animals were kept under treatment for twelve weeks, being fed a standard diet and treated with resveratrol via gavage. Body, biochemical, hormonal, and histological parameters were measured; in addition to the expression of markers associated with thermogenesis in brown adipose tissue. The results showed that animals supplemented with resveratrol showed reduced body weight and visceral adiposity, in addition to glucose, total cholesterol, and triglyceride levels; decreased serum FSH levels and increased estrogen levels were observed compared to the OOF group and mRNA expression of PRDM16, UCP1, and SIRT3 in brown adipose tissue. The findings of this study suggest the important role of resveratrol in terms of improving body, metabolic, and hormonal parameters, as well as modulating markers associated with thermogenesis in brown adipose tissue of female mice submitted to oophorectomy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Ovariectomia / Suplementos Nutricionais / Termogênese / Proteína Desacopladora 1 / Resveratrol Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Ovariectomia / Suplementos Nutricionais / Termogênese / Proteína Desacopladora 1 / Resveratrol Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda