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Change in Volumes and Location of Preterm White Matter Injury over a Period of 15 Years.
Selvanathan, Thiviya; Guo, Ting; Ufkes, Steven; Chau, Vann; Branson, Helen M; Synnes, Anne R; Ly, Linh G; Kelly, Edmond; Grunau, Ruth E; Miller, Steven P.
Afiliação
  • Selvanathan T; Pediatrics, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
  • Guo T; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Neuroscience & Mental Health, SickKids Research Institute, Toronto, Ontario, Canada.
  • Ufkes S; Pediatrics, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada.
  • Chau V; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Neuroscience & Mental Health, SickKids Research Institute, Toronto, Ontario, Canada.
  • Branson HM; Diagnostic Imaging, The Hospital for Sick Children and Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  • Synnes AR; Pediatrics, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada.
  • Ly LG; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
  • Kelly E; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Grunau RE; Pediatrics, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada.
  • Miller SP; Pediatrics, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada; Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Neuroscience & Mental Health, SickKids Research Institute, Toronto, Ontar
J Pediatr ; 272: 114090, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38754774
ABSTRACT

OBJECTIVE:

To evaluate whether white matter injury (WMI) volumes and spatial distribution, which are important predictors of neurodevelopmental outcomes in preterm infants, have changed over a period of 15 years. STUDY

DESIGN:

Five hundred and twenty-eight infants born <32 weeks' gestational age from 2 sequential prospective cohorts (cohort 1 2006 through 2012; cohort 2 2014 through 2019) underwent early-life (median 32.7 weeks postmenstrual age) and/or term-equivalent-age MRI (median 40.7 weeks postmenstrual age). WMI were manually segmented for quantification of volumes. There were 152 infants with WMI with 74 infants in cohort 1 and 78 in cohort 2. Multivariable linear regression models examined change in WMI volume across cohorts while adjusting for clinical confounders. Lesion maps assessed change in WMI location across cohorts.

RESULTS:

There was a decrease in WMI volume in cohort 2 compared with cohort 1 (ß = -0.6, 95% CI [-0.8, -0.3], P < .001) with a shift from more central to posterior location of WMI. There was a decrease in clinical illness severity of infants across cohorts.

CONCLUSIONS:

We found a decrease in WMI volume and shift to more posterior location in very preterm infants over a period of 15 years. This may potentially reflect more advanced maturation of white matter at the time of injury which may be related to changes in clinical practice over time.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido Prematuro / Imageamento por Ressonância Magnética / Substância Branca Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido Prematuro / Imageamento por Ressonância Magnética / Substância Branca Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos