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Crack cocaine inhalation increases seizure susceptibility by reducing acetylcholinesterase activity.
de Melo Bastos Cavalcante, Cibelle; Bruno Oliveira, Kellysson; Maria Araújo de Souza, Fernanda; Maria Jatobá Hasten Reiter, Milenna; Rodrigues Melo da Silva, Bianca; Lavínia da Silva Oliveira, Keylla; Vinicius Dos Santos Sales, Marcos; Larissa Dias Pacheco, Amanda; Santos Siqueira, Edite; de Araújo Costa, Maisa; Gomes Dos Santos Neto, José; Gabriely Duarte Torres, Rayssa; Catarina R Leite, Ana; Santana de Melo, Igor; Salgueiro Machado, Sônia; Duzzioni, Marcelo; Leite Góes Gitaí, Daniel; Wagner de Castro, Olagide.
Afiliação
  • de Melo Bastos Cavalcante C; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Bruno Oliveira K; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Maria Araújo de Souza F; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Maria Jatobá Hasten Reiter M; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Rodrigues Melo da Silva B; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Lavínia da Silva Oliveira K; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Vinicius Dos Santos Sales M; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Larissa Dias Pacheco A; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Santos Siqueira E; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • de Araújo Costa M; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Gomes Dos Santos Neto J; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Gabriely Duarte Torres R; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Catarina R Leite A; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Santana de Melo I; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Salgueiro Machado S; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Duzzioni M; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Leite Góes Gitaí D; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • Wagner de Castro O; Department of Physiology, Institute of Biological Science and Health of Federal University of Alagoas, Maceió, Alagoas, Brazil. Electronic address: olagidewww@gmail.com.
Epilepsy Behav ; 156: 109832, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38761450
ABSTRACT
Crack cocaine is a highly addictive and potent stimulant drug. Animal studies have shown that the cholinergic system plays a role in neurotoxicity induced by cocaine or its active metabolites inhalation. Behavioral alterations associated with crack cocaine use include hyperactivity, depressed mood, and decreased seizure threshold. Here we evaluate the acetylcholinesterase (AChE) and reactive oxygen species (ROS) activity, behavioral profile, and the threshold for epileptic seizures in rats that received intrahippocampal pilocarpine (H-PILO) followed by exposure to crack cocaine (H-PILO + CRACK). Animals exposed to H-PILO + CRACK demonstrated increased severity and frequency of limbic seizures. The AChE activity was reduced in the groups exposed to crack cocaine alone (CRACK) and H-PILO + CRACK, whereas levels of ROS remained unchanged. In addition, crack cocaine exposure increased vertical locomotor activity, without changing water and sucrose intake. Short-term memory consolidation remained unchanged after H-PILO, H-PILO + CRACK, and CRACK administration. Overall, our data suggest that crack cocaine inhalation reduced the threshold for epileptic seizures in rats submitted to low doses of pilocarpine through the inhibition of AChE. Taken together, our findings can be useful in the development of effective strategies for preventing and treating the harmful effects of cocaine and crack cocaine on the central nervous system.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pilocarpina / Acetilcolinesterase / Convulsões / Cocaína Crack / Ratos Wistar Limite: Animals Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pilocarpina / Acetilcolinesterase / Convulsões / Cocaína Crack / Ratos Wistar Limite: Animals Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos