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Interactions between TNFAIP3, PTPN22, and TRAF1-C5 gene polymorphisms in patients with primary Sjögren's syndrome.
Cadena-Sandoval, Daniel; Montúfar-Robles, Isela; Barbosa-Cobos, Rosa Elda; Hernández-Molina, Gabriela; Karen Salas-García, Ana; Sánchez-Zauco, Norma; Ramírez-Bello, Julian.
Afiliação
  • Cadena-Sandoval D; Universidad Juárez Autónoma De Tabasco, Comalcalco Multidisciplinary Academic Division, Comalcalco, Tabasco, Mexico.
  • Montúfar-Robles I; División De Investigación, Hospital Juárez De México, Ciudad De México, Mexico.
  • Barbosa-Cobos RE; Departamento De Reumatología, Hospital Juárez De México, Ciudad De México, Mexico.
  • Hernández-Molina G; Departamento De Inmunología Y Reumatología, Instituto Nacional De Ciencias Médicas Y Nutrición, Ciudad De México , Mexico.
  • Karen Salas-García A; Departamento De Reumatología, Hospital Juárez De México, Ciudad De México, Mexico.
  • Sánchez-Zauco N; División De Diagnostico Y Tratamientos Auxiliares, Centro Médico Nacional Siglo Xxi, Ciudad De México, Mexico.
  • Ramírez-Bello J; Subdirección de Investigación Clínica, Instituto Nacional De Cardiologia Ignacio Chávez, Ciudad De Mexico, Mexico.
Arch Rheumatol ; 39(1): 60-70, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38774701
ABSTRACT

Objectives:

The aim of our study was to investigate whether TNFAIP3, PTPN22, and TRAF1-5 single nucleotide polymorphisms (SNPs) are associated with susceptibility, severity, or serological markers in primary Sjögren's syndrome (pSS). Patients and

methods:

The cases and controls study was conducted between December 2021 and June 2022. TNFAIP3 rs10499194C/T, rs6920220G/A, and rs2230926T/G, PTPN22 rs2476601C/T and rs33996649G/A, and TRAF1-C5 rs10818488G/A polymorphisms were genotyped in 154 female pSS patients (mean age 45.2±6.8 years) and 313 female control subjects (mean age 50.3±7.5 years) using the TaqMan® SNP genotyping assay. An association analysis between TNFAIP3, PTPN22, and TRAF1-C5 SNPs and susceptibility, clinical characteristics, and serological markers of pSS was performed. Interactions between TNFAIP3, PTPN22, and TRAF1-C5 SNPs were also evaluated in patients and controls.

Results:

The genotype and allele frequencies showed no association with susceptibility, severity, or serological markers of pSS. Nevertheless, several interactions between TNFAIP3 and TRAF1-C5 or TNFAIP3, PTPN22, and TRAF1-C5 genotypes were associated with susceptibility to pSS (p<0.01).

Conclusion:

Individual TNFAIP3, PTPN22, and TRAF1-C5 SNPs are not associated with susceptibility, severity, or serological markers of pSS. However, genetic interactions between TRAF1-C5 and TNFAIP3 or TNFAIP3, PTPN22, and TRAF1-C5 SNPs are risk factors for pSS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Arch Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Turquia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Arch Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Turquia