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Ethnomedicinal Study and Evaluation of the Anxiolytic-like and Diuretic Effects of the Orchid Stanhopea tigrina Bateman ex Lindl-(Orchidaceae).
Del Carmen Díaz-Torres, Rocío; Yáñez-Barrientos, Eunice; Montes-Rocha, José Ángel; Morales-Tirado, David Jeremías; Alba-Betancourt, Clara; Gasca-Martínez, Deisy; Gonzalez-Rivera, Maria L; Del Carmen Juárez-Vázquez, María; Deveze-Álvarez, Martha Alicia; Isiordia-Espinoza, Mario Alberto; Carranza-Álvarez, Candy; Alonso-Castro, Angel Josabad.
Afiliação
  • Del Carmen Díaz-Torres R; Multidisciplinary Graduate Program in Environmental Sciences, Autonomous University of San Luis Potosí, San Luís Potosí 78000, Mexico.
  • Yáñez-Barrientos E; Department of Chemistry, University of Guanajuato, Guanajuato 36200, Mexico.
  • Montes-Rocha JÁ; School of Professional Studies Huasteca Zone, Autonomous University of San Luis Potosí, Ciudad Valles, San Luís Potosí 79059, Mexico.
  • Morales-Tirado DJ; Department of Chemistry, University of Guanajuato, Guanajuato 36200, Mexico.
  • Alba-Betancourt C; Department of Pharmacy, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato 36200, Mexico.
  • Gasca-Martínez D; Institute of Neurobiology, National Autonomous University of Mexico, Juriquilla 76230, Mexico.
  • Gonzalez-Rivera ML; Department of Pharmacy, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato 36200, Mexico.
  • Del Carmen Juárez-Vázquez M; Department of Pharmacy, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato 36200, Mexico.
  • Deveze-Álvarez MA; Department of Pharmacy, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato 36200, Mexico.
  • Isiordia-Espinoza MA; Medical Sciences Research Institute, University of Guadalajara, Tepatitlan, Guadalajara 472620, Mexico.
  • Carranza-Álvarez C; School of Professional Studies Huasteca Zone, Autonomous University of San Luis Potosí, Ciudad Valles, San Luís Potosí 79059, Mexico.
  • Alonso-Castro AJ; Department of Pharmacy, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato 36200, Mexico.
Pharmaceuticals (Basel) ; 17(5)2024 May 06.
Article em En | MEDLINE | ID: mdl-38794158
ABSTRACT
Stanhopea tigrina Bateman ex Lindl. (Orchidaceae) is an orchid endemic to Mexico, known as "Calavera" or "calaverita", in the Huasteca Potosina (central region of Mexico). This plant species is used for the folk treatment of mental disorders and urological kidney disorders, according to the ethnomedicinal information obtained in this study. Ethanolic extracts of leaves (HE) and pseudobulb (PE) were obtained by microwave-assisted extraction (MAE). Gas Chromatography coupled with Mass Spectrometry (GC-MS) was used to carry out the chemical characterization of HE and PE. The pharmacological effects (antioxidant, diuretic, anxiolytic, locomotor, hypnotic, and sedative) of HE and PE were evaluated. The possible mechanism of action of the anxiolytic-like activity induced by HE was assessed using inhibitors of the GABAergic, adrenergic, and serotonergic systems. The possible mechanism of the diuretic action of HE was assessed using prostaglandin inhibitory antagonists and nitric oxide synthase (NOS) blockers. HE at 50 and 100 mg/kg exerted anxiolytic-like activity without inducing hypnosis or sedation. Flumazenil, prazosin, and ketanserin inhibited the anxiolytic-like activity shown by HE, which suggests the participation of GABA, α1-adrenergic receptors, and 5-HT2 receptors, respectively. The diuretic effect was reversed by the non-selective NOS inhibitor L-NAME, which caused the reduction in nitric oxide (NO). These results demonstrate that the ethanolic extract of S. tigrina leaves exhibited anxiolytic-like activity and diuretic effects without inducing hypnosis or sedation. This work validates the medicinal uses of this orchid species.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça