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[Microorganisms isolated from blood cultures and resistance profile in children with cancer and high-risk febrile neutropenia. Red PINDA, Chile, 2016-2021]. / Microorganismos aislados de hemocultivos y su perfil de resistencia en niños con cáncer y neutropenia febril de alto riesgo. Red PINDA, Chile, 2016-2021.
Valenzuela, Romina; Riquelme, Carolina; de la Maza, Verónica; Álvarez, Ana María; Contardo, Verónica; Ducasse, Karen; Payá, Ernesto; Claverie, Ximena; Venegas, Marcela; Santolaya, María Elena.
Afiliação
  • Valenzuela R; Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • Riquelme C; Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • de la Maza V; Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • Álvarez AM; Departamento de Pediatría, Hospital San Juan de Dios, Santiago, Chile.
  • Contardo V; Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • Ducasse K; Departamento de Pediatría, Hospital Gustavo Fricke, Viña del Mar, Chile.
  • Payá E; Departamento de Pediatría, Hospital Exequiel González Cortés, Santiago, Chile.
  • Claverie X; Departamento de Pediatría, Hospital Dr. Sótero del Río, Santiago, Chile.
  • Venegas M; Departamento de Pediatría, Hospital San Borja Arriarán, Santiago, Chile.
  • Santolaya ME; Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Andes Pediatr ; 95(2): 143-150, 2024 Apr.
Article em Es | MEDLINE | ID: mdl-38801361
ABSTRACT
Bacteremia is a major cause of morbidity and mortality in patients with cancer and episodes of high-risk febrile neutropenia (HRFN).

OBJECTIVE:

To identify the frequency of microorganisms isolated from blood cultures (BC) and their antimicrobial resistance (R) profile in children with HRFN, compared with the same data from previous studies of the same group.

METHOD:

Prospective, multicenter, epidemiological surveillance study of microorganisms isolated from BC in patients under 18 years of age, from 7 PINDA network hospitals, between 2016 and 2021.

RESULTS:

284 episodes of HRFN with positive BC were analyzed out of 1091 enrolled episodes (26%). Median age 7.2 years [3.0-12.3]. The main isolates were gram-negative bacilli (GNB) 49.2%, gram-positive cocci (GPC) 43.8%, and fungi 3.6%. The most frequently isolated microorganisms were viridans group Streptococci (VGS) (25.8%), Escherichia coli (19.8%), Pseudomonas spp. (11.2%), Klebsiella spp. (10.9%), and coagulase negative Staphylococci (CoNS) (10.9%). There was an increase in R to third-generation cephalosporins (p = 0.011) in GNB and to oxacillin in CoNS (p = 0.00), as well as a decrease in R to amikacin in non-fermenting GNB (p = 0.02) and to penicillin in VGS (p = 0.04).

CONCLUSION:

VGS is the main agent isolated in BC from pediatric patients with cancer and episodes of HRFN, followed by E. coli, Pseudomonas spp., and Klebsiella spp. Having epidemiological surveillance of microorganisms isolated from BC and their antimicrobial R profile is essential to favor the rational use of antimicrobials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bacteriemia / Neutropenia Febril / Hemocultura / Antibacterianos / Neoplasias Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do sul / Chile Idioma: Es Revista: Andes Pediatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bacteriemia / Neutropenia Febril / Hemocultura / Antibacterianos / Neoplasias Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do sul / Chile Idioma: Es Revista: Andes Pediatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile