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Multiple-target Therapy for Posttransplant Focal Segmental Glomerulosclerosis.
Mansur, Juliana; Chang-Dávila, Domingo; Simões, Marcela Giraldes; Cristelli, Marina Pontello; Stopa Martins, Suelen Bianca; de Sousa Proença, Henrique Machado; Viana, Laila Almeida; Ferreira, Alexandra Nicolau; Doher, Marisa Petrucelli; Medina-Pestana, José; Mastroianni Kirsztajn, Gianna; Tedesco-Silva, Helio.
Afiliação
  • Mansur J; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Chang-Dávila D; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
  • Simões MG; Universidade Peruana Cayetano Heredia, Lima, Peru.
  • Cristelli MP; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Stopa Martins SB; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
  • de Sousa Proença HM; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Viana LA; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Ferreira AN; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Doher MP; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Medina-Pestana J; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
  • Mastroianni Kirsztajn G; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
  • Tedesco-Silva H; Nephrology Division, Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, Brazil.
Transplant Direct ; 10(6): e1651, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38817628
ABSTRACT

Background:

There is no consensus on the ideal strategy to treat posttransplant focal segmental glomerulosclerosis. The multiple-target therapy, which consisted of high-dose intravenous cyclosporine, prednisone, and plasmapheresis, showed favorable results.

Methods:

This single-center, prospective study sought to evaluate the multiple-target therapy in an independent cohort of patients.

Results:

Thirteen patients with posttransplant focal segmental glomerulosclerosis received multiple-target therapy. Complete remission was achieved in 2 patients (15.4%), and partial remission in another 2 patients (15.4%). Four patients (30.7%) did not show remission, and 5 patients (38%) lost the graft because of posttransplant focal segmental glomerulosclerosis during the 12-mo follow-up. Premature discontinuation of treatment occurred in 10 patients (77%), all associated with infectious adverse events. Cytomegalovirus was the most common complication, and preemptive therapy was used instead of prophylaxis.

Conclusions:

In this cohort of patients, the efficacy of the multiple-target therapy was poor and limited by the high incidence of infectious adverse events.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transplant Direct Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transplant Direct Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos