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Maternal and perinatal health indicators in Brazil over a decade: assessing the impact of the COVID-19 pandemic and SARS-CoV-2 vaccination through interrupted time series analysis.
Carvalho-Sauer, Rita; Costa, Maria da Conceição Nascimento; Teixeira, Maria Gloria; Flores-Ortiz, Renzo; Leal, Jessidenes Teixeira de Freitas Mendes; Saavedra, Ramon; Paixao, Enny S.
Afiliação
  • Carvalho-Sauer R; State Health Department of Bahia, Institute of Collective Health of the Federal University of Bahia, Brazil.
  • Costa MDCN; Institute of Collective Health of the Federal University of Bahia, Brazil.
  • Teixeira MG; Institute of Collective Health of the Federal University of Bahia, Brazil.
  • Flores-Ortiz R; Center for Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Brazil.
  • Leal JTFM; Municipal Health Department of Salvador, Institute of Collective Health of the Federal University of Bahia, Brazil.
  • Saavedra R; State Health Department of Bahia, Institute of Collective Health of the Federal University of Bahia, Brazil.
  • Paixao ES; London School of Hygiene and Tropical Medicine, England.
Lancet Reg Health Am ; 35: 100774, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38828284
ABSTRACT

Background:

Few studies have evaluated the effects of the Coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 virus, on maternal and perinatal health at a populational level. We investigated maternal and perinatal health indicators in Brazil, focusing on the effects of the COVID-19 pandemic, and SARS-CoV-2 vaccination campaign for pregnant women.

Methods:

Utilizing interrupted time series analysis (January 2013-December 2022), we examined Maternal Mortality Ratio, Perinatal Mortality Rate, Preterm Birth Rate, Cesarean Section Rate, and other five indicators. Interruptions occurred at the pandemic's onset (March 2020) and pregnant women's vaccination (July 2021). Results were expressed as percent changes on time series' level and slope.

Findings:

The COVID-19 onset led to immediate spikes in Maternal Mortality Ratio (33.37%) and Perinatal Mortality Rate (3.20%) (p < 0.05). From March 2020 to December 2022, Cesarean Section and Preterm Birth Rates exhibited upward trends, growing monthly at 0.13% and 0.23%, respectively (p < 0.05). Post start of SARS-CoV-2 vaccination (July 2021), Maternal Mortality Ratio (-34.10%) and Cesarean Section Rate (-1.87%) promptly declined (p < 0.05). Subsequently, we observed a monthly decrease of Maternal Mortality Ratio (-9.43%) and increase of Cesarean Section Rate (0.25%) (p < 0.05), while Perinatal Mortality Rate and Preterm Birth Rate showed a stationary pattern.

Interpretation:

The pandemic worsened all analyzed health indicators. Despite improvements in Maternal Mortality Ratio, following the SARS-CoV-2 vaccination campaign for pregnant women, the other indicators continued to sustain altered patterns from the pre-pandemic period.

Funding:

No funding.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Lancet Reg Health Am Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Lancet Reg Health Am Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido