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Unravelling the analgesic effects of perioperative magnesium in general abdominal surgery: a systematic review and meta-analysis of randomized controlled trials.
Avci, Yasin; Rajarathinam, Manikandan; Kalsekar, Neha; Tawfic, Qutaiba; Krause, Sarah; Nguyen, Derek; Liu, Eric; Nagappa, Mahesh; Subramani, Yamini.
Afiliação
  • Avci Y; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Rajarathinam M; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Kalsekar N; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Tawfic Q; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Krause S; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Nguyen D; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Liu E; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Nagappa M; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
  • Subramani Y; Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada. Electronic address: Yamini.Subramani@lhsc.on.ca.
Braz J Anesthesiol ; 74(4): 844524, 2024.
Article em En | MEDLINE | ID: mdl-38848810
ABSTRACT

BACKGROUND:

Prior research has established the effectiveness of magnesium in relieving postoperative pain. This article aims to evaluate magnesium sulfate for perioperative analgesia in adults undergoing general abdominal surgery under general anesthesia.

OBJECTIVE:

The primary aim was to assess pain scores at 6 and 24 hours postoperatively in patients receiving magnesium sulfate vs. the control group. Secondary outcomes were postoperative opioid consumption, perioperative complications, and time to rescue analgesia.

METHODS:

A comprehensive database search identified studies comparing magnesium sulfate with control in adults undergoing general anesthesia for general abdominal surgery. Using random-effects models, data were presented as mean ± Standard Deviation (SD) or Odds Ratios (OR) with corresponding 95% Confidence Intervals (95% CI). A two-sided p-value < 0.05 was considered statistically significant.

RESULTS:

In total, 31 studies involving 1762 participants met the inclusion criteria. The magnesium group showed significantly lower postoperative pain scores at both early (within six hours) and late (up to 24 hours) time points compared to the control group. The early mean score was 3.1 ± 1.4 vs. 4.2 ± 2.3, and the late mean score was 2.3 ± 1.1 vs. 2.7 ± 1.5, resulting in an overall Mean Difference (MD) of -0.72; 95% CI -0.99, -0.44; p < 0.00001. The magnesium group was associated with lower rates of postoperative opioid consumption and shivering and had a longer time to first analgesia administration compared to the saline control group.

CONCLUSION:

Magnesium sulfate administration was linked to reduced postoperative pain and opioid consumption following general abdominal surgery.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor Pós-Operatória / Ensaios Clínicos Controlados Aleatórios como Assunto / Abdome / Analgésicos / Sulfato de Magnésio Limite: Humans Idioma: En Revista: Braz J Anesthesiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor Pós-Operatória / Ensaios Clínicos Controlados Aleatórios como Assunto / Abdome / Analgésicos / Sulfato de Magnésio Limite: Humans Idioma: En Revista: Braz J Anesthesiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá País de publicação: Brasil