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Lysine grafted poly(lactic acid): An intrinsically antimicrobial polymer.
Dorm, Bruna Carolina; Bastos, Anielly Costa; Nossa, Tamires Souza; Neto, Benedito Domingos; Iemma, Mônica Rosas Costa; Carvalho, Antonio José Felix; Trovatti, Eliane.
Afiliação
  • Dorm BC; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, 14801-340 Araraquara, SP, Brazil.
  • Bastos AC; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, 14801-340 Araraquara, SP, Brazil.
  • Nossa TS; Laboratory of Materials (LabMat) and Laboratory of Biopolymers (LaBioPol), Federal Institute of Education, Science and Technology of São Paulo, Av. João Olímpio de Oliveira, 1561, 18202-000 Itapetininga, SP, Brazil.
  • Neto BD; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, 14801-340 Araraquara, SP, Brazil.
  • Iemma MRC; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, 14801-340 Araraquara, SP, Brazil.
  • Carvalho AJF; Department of Materials Engineering, São Carlos School of Engineering, University of São Paulo, Av. João Dagnone, 1100 13563-120 São Carlos, SP, Brazil.
  • Trovatti E; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, 14801-340 Araraquara, SP, Brazil. Electronic address: elianetrov@yahoo.com.br.
Int J Biol Macromol ; 273(Pt 2): 133181, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38880447
ABSTRACT
Nosocomial infections or healthcare-associated infections, normally develops after the healthcare treatment in the hospital. Most of them are caused by infected medical devices. Plastics are the most common materials for manufacturing these devices because of their good processability, sterilization efficacy, ease of handling and harmlessness, however, it usually do not display antimicrobial properties. Here, in order to infer antimicrobial activity to poly(lactic acid), it was modified by maleation, followed by l-lysine grafting to its structure. The chemical modifications were confirmed by FTIR and 1H NMR analysis, indicating the success of the reactions. The antimicrobial activity was tested using Escherichia coli and Staphylococcus aureus and the results showed that the sample was capable of inhibiting about 99 % of the S. aureus growth by contact. The samples cytotoxicity was also tested using the L929 mouse cells and the results indicated no cytotoxic effect. These results indicated the sample antimicrobial potential, without affect the normal eukaryotic cells. In addition, the processability of the modified PLA (PLA-g-Lys) was improved without compromising its mechanical properties, as shown by thermal analysis and tensile tests. Thus, this novel PLA derivative can be seen as a promising material for future applications in the manufacturing of biomedical devices.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Staphylococcus aureus / Escherichia coli / Lisina Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Staphylococcus aureus / Escherichia coli / Lisina Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda