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Impaired Quality of Life in Patients with Post-Surgical Hypoparathyroidism.
Ivanovic-Zuvic, Danisa; Chelebifski, Slavka; Uribe, Benjamin; Quintana, Camila; Domínguez, José Miguel; Olmos, Roberto; Florenzano, Pablo.
Afiliação
  • Ivanovic-Zuvic D; Department of Endocrinology, Hospital del Salvador, Santiago, Chile.
  • Chelebifski S; School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Uribe B; School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Quintana C; School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Domínguez JM; Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Olmos R; Centro Traslacional de Endocrinología (CETREN-UC), School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Florenzano P; Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
J Bone Metab ; 31(2): 140-149, 2024 May.
Article em En | MEDLINE | ID: mdl-38886971
ABSTRACT

BACKGROUND:

Hypoparathyroidism is characterized by chronic hypocalcemia with low or abnormal parathyroid hormone levels. Thyroid surgery remains a predominant cause of hypoparathyroidism, often preventable by partial thyroidectomy. Although hypoparathyroidism can impair quality of life (QOL), data remain limited for Latin America. We aimed to characterize clinical manifestations and QOL in patients with postsurgical hypoparathyroidism.

METHODS:

This case-control study included patients (>18 years) who underwent total thyroidectomy (TT) for differentiated thyroid cancer (DTC) with postsurgical hypoparathyroidism (Group 1, Cases) and those with DTC who underwent TT without postsurgical hypoparathyroidism (Group 2, Controls). Clinical records were collected, and the SF-36v2 QOL survey and a structured symptom survey were applied. A logistic multivariate regression analysis was performed.

RESULTS:

This study included 106 subjects (Group 1, N=41; Group 2, N=65). Group 1 patients were younger, had a higher frequency of lymph node resection, and more frequently received Ι-131 than Group 2 patients (p<0.05). In the SF-36v2 survey, Group 1 had fewer physical-functioning scores (odds ratio, 3.8; 95% confidence interval, 1.2-11.7) and lower scores in mental and physical components than Group 2 and national records. Commonly reported symptoms include paresthesia, daily fatigue, and memory alterations. Treatment adherence rates were 56% and 71% for calcium and calcitriol, respectively. Furthermore, 24% of patients experienced one or more hypoparathyroidism drug-related adverse effects.

CONCLUSIONS:

Patients with postsurgical hypoparathyroidism had an impaired QOL, a high frequency of disease-associated symptoms, and limited treatment adherence. These results should be considered when deciding the best surgical alternative for DTC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Bone Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação:
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Bone Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: