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Rapid and long-lasting effects of subcutaneous esketamine on suicidality: An open-label study in patients with treatment-resistant depression.
Lopes, Eduardo Igor Torquato Cardoso; Cavalcanti-Ribeiro, Patrícia; Palhano-Fontes, Fernanda; Gonçalves, Kaike Thiê da Costa; Nunes, Emerson Arcoverde; Lima, Nicole Bezerra de Medeiros; Santos, Nestor Caetano; Brito, Aldielyson Jorge Cavalcante de; de Araujo, Draulio Barros; Galvão-Coelho, Nicole Leite.
Afiliação
  • Lopes EITC; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Cavalcanti-Ribeiro P; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Psychobiology and Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal- RN, Brazil; Onofre Lopes Universi
  • Palhano-Fontes F; Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Gonçalves KTDC; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Nunes EA; Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Clinical Medicine, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Lima NBM; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Santos NC; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Brito AJC; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Araujo DB; Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Galvão-Coelho NL; Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Psychobiology and Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal- RN, Brazil; Western Sydney Univer
J Psychiatr Res ; 176: 254-258, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38901389
ABSTRACT
Therapeutics for suicide management is limited, taking weeks to work. This open-label clinical trial with 18 treatment-resistant depressive patients tested subcutaneous esketamine (8 weekly sessions) for suicidality. We noted a rapid and enduring effect of subcutaneous esketamine, lasting from one week to six months post-treatment, assessed by the Beck Inventory for Suicidality (BSI). There was an immediate drop in suicidality, 24 h following the initial dose, which persisted for seven days throughout the eight-week dosing period. Additionally, this study is the first to examine a six-month follow-up after multiple administrations of subcutaneous esketamine, finding consistently lower levels of suicidality throughout this duration. Conversely, suicidality also was measured along the 8-weeks of treatment by a psychiatrist using the Montgomery-Asberg Depression Rating Scale (MADRS), which showed significant reduction only after two treatment sessions expanding until the last session. Moreover, notably, 61% of patients achieved remission on suicidality (MADRS). These results suggest that weekly subcutaneous esketamine injections offer a cost-effective approach that induces a rapid and sustained response to anti-suicide treatment. This sets the stage for further, more controlled studies to corroborate our initial observations regarding the effects of SC esketamine on suicidality. Registered trial at https//ensaiosclinicos.gov.br/rg/RBR-1072m6nv.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ideação Suicida / Transtorno Depressivo Resistente a Tratamento / Ketamina / Antidepressivos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychiatr Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ideação Suicida / Transtorno Depressivo Resistente a Tratamento / Ketamina / Antidepressivos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychiatr Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido