Effects of Adipose-derived Stem Cells in the Treatment of Knee Osteoarthritis: A Case Report in Brazil's Unified Health System.

Schweich-Adami, Laynna de Carvalho; Silva, Roberto Antoniolli da; Baranoski, Adrivanio; Kassuya, Candida Aparecida Leite; Antoniolli-Silva, Andréia Conceição Milan Brochado; Oliveira, Rodrigo Juliano

Schweich-Adami, Laynna de Carvalho; Silva, Roberto Antoniolli da; Baranoski, Adrivanio; Kassuya, Candida Aparecida Leite; Antoniolli-Silva, Andréia Conceição Milan Brochado; Oliveira, Rodrigo Juliano.

Afiliação

Schweich-Adami LC; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil.
Silva RAD; Programa de Pós-Graduação em Saúde e Desenvolvimento da Região Centro-Oeste, Faculdade de Medicina Dr. Hélio Mandetta - Famed, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande MS, Brazil.
Baranoski A; Ambulatório de Ortopedia e Traumatologia, Hospital Universitário Maria Aparecida Pedrossian - HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil.
Kassuya CAL; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil.
Antoniolli-Silva ACMB; Faculdade de Ciências da Saúde - FCS, Universidade Federal da Grande Dourados - UFGD, Dourados, MS, Brasil.
Oliveira RJ; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil.

Rev Bras Ortop (Sao Paulo) ; 59(3): e471-e474, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38911897

ABSTRACT

ABSTRACT

Osteoarthritis (OA) can incapacitate the individual to perform their activities of daily living due to pain. This is an important public health issue that worsens worldwide and in Brazil, since the population goes through an aging process, and has caused increased public spending on the monitoring and maintenance of treatments that can last for years and still not be resolutive. Thus, the search for innovative and effective therapies that can reduce costs becomes necessary. In this context, the present study reports the first application of cell therapy with adipose-derived stem cells in the treatment of cases of OA that are refractory to the conservative treatment, performed in the Brazilian Unified Health System (Sistema Único de Saúde, SUS). The evaluation was performed with the application of the Visual Analog Scale (VAS), the Short Form Health Survey (SF-36) and the Western Ontario and McMaster Universities (WOMAC), specifics for OA evaluation, and also an analysis of the synovial fluid (inflammatory cytokines). The cell therapy improved the scores on the WOMAC, SF-36 and EVA, and reduced the inflammatory process. We observed a decrease of 0.73x in the TNF, of 0,71x in IL-1b, of 0,68x in IL-8, and of 0,70x in IL-10. For IL-6, an increase of 1,48x was observed. Therefore, this cell therapy can be considered promising in aiding the management of this disease, since it improved the patient's pain, decrease inflammatory markers, and enabled the return to activities of daily living, which resulted in an improvement in their quality of life.

Palavras-chave

Unified Health System; cell therapy; inflammation; joint pain; orthopedics; regenerative medicine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Bras Ortop (Sao Paulo) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

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