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Botulinum Toxin and Deep Brain Stimulation in Dystonia.
de Souza, Julia Carvalhinho Carlos; Falcone, Ananda Carolina Moraes; Barbosa, Renata Montes Garcia; Soares, Miriam Carvalho; Munhoz, Renato; Farah, Marina; Capato, Tamine; Casagrande, Sara Carvalho Barbosa; Cordellini, Marcela Ferreira; de Castro Micheli, Gabriel; Limongi, João Carlos Papaterra; Barbosa, Egberto Reis; Listik, Clarice; Cury, Rubens Gisbert.
Afiliação
  • de Souza JCC; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Falcone ACM; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Barbosa RMG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Soares MC; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Munhoz R; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada.
  • Farah M; Cajuru University Hospital, Pontíficia Universidade Católica do Paraná, Curitiba 80050-350, Brazil.
  • Capato T; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Casagrande SCB; Department of Neurology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
  • Cordellini MF; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • de Castro Micheli G; Instituto de Neurologia de Curitiba, Curitiba 81210-310, Brazil.
  • Limongi JCP; Department of Neurology, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Barbosa ER; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Listik C; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Cury RG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
Toxins (Basel) ; 16(6)2024 Jun 20.
Article em En | MEDLINE | ID: mdl-38922176
ABSTRACT
Deep Brain Stimulation (DBS) is a recognized treatment for different dystonia subtypes and has been approved by the Food and Drug Administration (FDA) since 2003. The European Federation of Neurological Societies (EFNS) and the International Parkinson and Movement Disorders Society (MDS) recommend DBS for dystonia after failure of botulinum toxin (BoNT) and other oral medications for dystonia treatment. In addition, several long-term studies have demonstrated the continuous efficacy of DBS on motor and quality of life (QoL) scores. However, there are only a few reports comparing the overall impact of surgical treatment in BoNT protocols (e.g., dosage and number of selected muscles before and after surgery). This retrospective multicenter chart-review study analyzed botulinum toxin total dosage and dosage per muscle in 23 dystonic patients before and after DBS surgery. The study's primary outcome was to analyze whether there was a reduction in BoNT dosage after DBS surgery. The mean BoNT dosages difference between baseline and post-surgery was 293.4 units for 6 months, 292.6 units for 12 months, and 295.2 units at the last visit. The median total dose of BoNT in the preoperative period was 800 units (N = 23). At the last visit, the median was 700 units (p = 0.05). This represents a 12.5% reduction in BoNT median dosage. In conclusion, despite the limitations of this retrospective study, there was a significant reduction in BoNT doses after DBS surgery in patients with generalized dystonia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Distonia Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Toxins (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Distonia Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Toxins (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça