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Sofosbuvir Off-label Treatment of Yellow Fever Patients During an Outbreak in Brazil, 2018: A Cohort Study.
Rezende, Izabela M; Mendonça, Diogo Correa; Costa, Thais Alkifeles; de Oliveria, Gabriela Fernanda Garcia; Arruda, Matheus Soares; Gonçalves, Andreza Parreiras; Alves, Pedro Augusto; Calzavara-Silva, Carlos Eduardo; Martins-Filho, Olindo A; Teixeira-Carvalho, Andréa; Bonjardim, Claudio Antonio; Monath, Thomas P; LaBeaud, A Desiree; Drumond, Betânia P; Pascoal-Xavier, Marcelo Antônio; Pereira, Leonardo S; Ramalho, Dario Brock.
Afiliação
  • Rezende IM; Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
  • Mendonça DC; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Costa TA; Centre for Virus Research, Medical Research Council/University of Glasgow, Glasgow, United Kingdom.
  • de Oliveria GFG; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Arruda MS; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Gonçalves AP; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Alves PA; Immunology of Viral Diseases, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Calzavara-Silva CE; Immunology of Viral Diseases, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Martins-Filho OA; Cellular and Molecular Immunology, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Teixeira-Carvalho A; Integrated Group of Biomarkers Research, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Bonjardim CA; Integrated Group of Biomarkers Research, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Monath TP; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • LaBeaud AD; Crozet BioPharma LLC, Lexington, Massachusetts, USA.
  • Drumond BP; Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
  • Pascoal-Xavier MA; Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Pereira LS; Immunology of Viral Diseases, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
  • Ramalho DB; Eduardo de Menezes Hospital, Belo Horizonte, Minas Gerais, Brazil.
Open Forum Infect Dis ; 11(6): ofae312, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38933737
ABSTRACT
We enrolled 21 patients with laboratory-confirmed yellow fever (YF), hospitalized at Eduardo de Menezes Hospital, Brazil, to be treated with sofosbuvir, a drug approved for hepatitis C. Given the absence of specific YF antiviral treatments, the off-label nonrandomized sofosbuvir treatment aimed to address high disease severity and the risk of fatal outcomes. Patients received a daily dose of 400 mg sofosbuvir from 4 to 10 days post-symptom onset. YF viral load (VL) comparisons were made between treated and nontreated patients who either survived or died. The genomic VL for the treated group steadily decreased after day 7 post-symptom onset, suggesting that sofosbuvir might reduce YF VL. This study underscores the urgent need for YF antiviral therapies, advocating for randomized clinical trials to further explore sofosbuvir's role in YF treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos