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Green synthesis of gold nanoparticles in an animal model of chronic wound induced with Resiquimod.
Mendes, Carolini; Zaccaron, Rubya Pereira; Casagrande, Laura de Roch; Venturini, Ligia Milanez; da Costa, Camila; Lima, Igor Ramos; Wermuth, Tiago Bender; Arcaro, Sabrina; Feuser, Paulo Emilio; Lock Silveira, Paulo Cesar.
Afiliação
  • Mendes C; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Zaccaron RP; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Casagrande LR; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Venturini LM; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • da Costa C; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Lima IR; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Wermuth TB; Biomaterials and Nanostructured Materials Research Group, Postgraduate Program in Materials Science and Engineering, Universidade do Extremo Sul Catarinense, UNESC, Criciúma, Santa Catarina, Brazil.
  • Arcaro S; Biomaterials and Nanostructured Materials Research Group, Postgraduate Program in Materials Science and Engineering, Universidade do Extremo Sul Catarinense, UNESC, Criciúma, Santa Catarina, Brazil.
  • Feuser PE; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
  • Lock Silveira PC; Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
J Drug Target ; : 1-15, 2024 Jul 12.
Article em En | MEDLINE | ID: mdl-38980282
ABSTRACT
Cost-effective strategies for the treatment of chronic wounds must be developed. The green synthesis of gold nanoparticles (GNPs) it is possible to guarantee a lower toxicity in biological tissues and greater safety of applicability, in addition to adding the effects of nanoparticles (NPs) to those of extracts. The objective of this study was to evaluate the effects of treatment with biosynthesized GNPs in a chronic wound model. Wistar rats were distributed into 7 groups Acute Wound (AW); Chronic wound (CW); CW + GNPs-Açaí; CW + GNPs-DB; CW + AV-GNPs; CW + SafGel®; CW + 660 nm laser. The chronic injury model was induced with topically applied Resiquimod for 6 days. Treatments were then initated on the fourteenth day after the last application of Resiquimod and carried out daily for ten days. The proposed therapies with GNPs were able to significantly reduce the inflammatory score and increase the rate of wound contraction. In histology, there was a reduction in the inflammatory infiltrate and increased gene expression of fibronectin and type III collagen, mainly in the CW + AV-GNPs group. The therapies were able to reduce pro-inflammatory cytokines, increase anti-inflammatory cytokines, and reduce oxidative stress. The results demonstrated that the effects of GNPs appear to complement those of the extracts, thereby enhancing the tissue repair process.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Drug Target Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Drug Target Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido