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A low-cost, portable device for the study of the malaria parasite's growth inhibition via microwave exposure.
Rua, Esteban; Coronado, Lorena; Donado Morcillo, Carlos A; Correa, Ricardo; Solís, Lina; Spadafora, Carmenza; Von Chong, Alejandro.
Afiliação
  • Rua E; School of Electrical Engineering, Universidad Tecnológica de Panamá, Víctor Levi Sasso Campus, Panama City, Panama.
  • Coronado L; Sistema Nacional de Investigación-SENACYT, Panama City, Panama.
  • Donado Morcillo CA; Biomedical Physics and Engineering Unit, Center of Cellular and Molecular Biology of Diseases (CBCMe), Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City, Panama.
  • Correa R; Biomedical Physics and Engineering Unit, Center of Cellular and Molecular Biology of Diseases (CBCMe), Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City, Panama.
  • Solís L; Biomedical Physics and Engineering Unit, Center of Cellular and Molecular Biology of Diseases (CBCMe), Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City, Panama.
  • Spadafora C; Biomedical Physics and Engineering Unit, Center of Cellular and Molecular Biology of Diseases (CBCMe), Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City, Panama.
  • Von Chong A; Sistema Nacional de Investigación-SENACYT, Panama City, Panama.
HardwareX ; 19: e00540, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38988372
ABSTRACT
Recently, a novel method for the growth inhibition of malaria parasites using microwaves was proposed. However, the apparatuses used to demonstrate this method are high-cost and immovable, hindering the progression in this field of research, which is still in its early stages. This paper presents the redesign, construction, and validation of an equivalent system, converting it into a portable and low-cost system, capable of replacing the existing one. The proposed system is mainly composed of an RF generator (MAX2870), an RF amplifier (SKYWORKS 66292-11) and a graphical user interface. Likewise, the RF applicator proposed by the original study was redesigned, resulting in a five-fold improvement in return loss. The obtained results indicate that the proposed system achieves 90% parasite growth inhibition, matching the performance of its counterpart at less than 1% of its cost. These results represent a breakthrough for the creation of smaller, enhanced devices that open new possibilities for an alternative treatment to combat this devastating disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: HardwareX Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Panamá País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: HardwareX Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Panamá País de publicação: Reino Unido