A rare case of Sporadic Creutzfeldt-Jakob disease at a remote mountain hospital in the Indian Himalayan Region.

Sharma, Nitu; Sharma, Jitender Kumar; Chander, Ashima; Shergill, Khushdeep; Yadav, Meghna

Sharma, Nitu; Sharma, Jitender Kumar; Chander, Ashima; Shergill, Khushdeep; Yadav, Meghna.

Afiliação

Sharma N; Military Hospital Ambala Cantt, Department of Pathology, Ambala Cantt, India.
Sharma JK; Army College of Medical Sciences, Base Hospital Delhi Cantt, New Delhi, India.
Chander A; Army College of Medical Sciences, Base Hospital Delhi Cantt, New Delhi, India.
Shergill K; Military Hospital Ambala Cantt, Department of Pathology, Ambala Cantt, India.
Yadav M; Military Hospital Bareilly, Department of Pathology, Bareilly, India.

Autops Case Rep ; 14: e2024502, 2024.

Article em En | MEDLINE | ID: mdl-39021461

ABSTRACT

ABSTRACT

Sporadic Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative spongiform encephalopathy that causes neuronal derangement secondary to prion protein. Its initial diagnosis is often complex and challenging due to non-specific clinical presentation, lack of awareness, and low clinical suspicion. This disease is invariably fatal, and most patients die within 12 months of presentation. Definite diagnosis of prion disease requires neuropathological analysis, usually done at autopsy. Here, we present the autopsy findings of a 57-year-old male patient, illustrating the complexity of diagnosing this disease early in the clinical course and the need for a broad differential diagnosis at the onset.

Palavras-chave

Autopsy; Creutzfeldt-Jakob Disease; Electroencephalography; Neuropathology; Prions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Autops Case Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil

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