Your browser doesn't support javascript.
loading
Hyperbaric oxygen therapy increases the effect of 5-fluorouracil chemotherapy on experimental colorectal cancer in mice.
Machado, Vanessa Foresto; da Rocha, José Joaquim Ribeiro; Parra, Rogério Serafim; Feitosa, Marley Ribeiro; Leite, Caio Abner; Minto, Stefânia Bovo; Garcia, Sérgio Britto; Cunha, Thiago Mattar; Feres, Omar.
Afiliação
  • Machado VF; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
  • da Rocha JJR; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
  • Parra RS; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
  • Feitosa MR; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
  • Leite CA; Department of Pharmacology, School of Medicine of Ribeirão Preto, USP, Ribeirão Preto, Brazil.
  • Minto SB; Pathology and Legal Medicine Department, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Garcia SB; Pathology and Legal Medicine Department, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Cunha TM; Department of Pharmacology, School of Medicine of Ribeirão Preto, USP, Ribeirão Preto, Brazil.
  • Feres O; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
Med Gas Res ; 14(3): 121-126, 2024 Sep 01.
Article em En | MEDLINE | ID: mdl-39073340
ABSTRACT
Tumor hypoxia may compromise the results of chemotherapy for treating colorectal cancer because it stimulates angiogenesis and the release of tumor growth factors. Hyperbaric oxygen (HBO) supplementation may potentiate the effects of chemotherapy in such cases. This study aimed to assess the effect of HBO therapy combined with chemotherapy on the treatment of colorectal cancer in mice. C57BL6 mice were submitted to the intrarectal instillation of N-methyl-N-nitrosoguanidine (MNNG) and treated with 5-fluorouracil (5FU) and/or HBO therapy. The MNNG group presented the highest dysplastic crypt rate. The 5FU + HBO group presented the highest rate of apoptotic cells per dysplastic crypt. The 5FU group presented the highest expression of hypoxia-inducible factor-1 alpha and CD44. HBO therapy increased the effect of 5FU on the treatment of the experimental colorectal neoplasia in mice.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Fluoruracila / Oxigenoterapia Hiperbárica / Camundongos Endogâmicos C57BL Limite: Animals Idioma: En Revista: Med Gas Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Fluoruracila / Oxigenoterapia Hiperbárica / Camundongos Endogâmicos C57BL Limite: Animals Idioma: En Revista: Med Gas Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália