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Antihyperalgesic effect of γ-terpinene complexed in ß-cyclodextrin on neuropathic pain model induced by tumor cells.
Pina, Lícia T S; Rabelo, Thallita K; Borges, Lysandro P; S S Gonçalves, Vitória; Silva, Akleyton S; Oliveira, Marlange A; S S Quintans, Jullyana; Quintans Júnior, Lucindo J; Scotti, Luciana; Scotti, Marcus T; da Silva Júnior, Evandro G; Douglas Melo Coutinho, Henrique; Guimarães, Adriana G.
Afiliação
  • Pina LTS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • Rabelo TK; Harquail Centre for Neuromodulation, Sunnybrook Helth Sciences Centre, University of Toronto, Ontario, Canada.
  • Borges LP; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • S S Gonçalves V; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • Silva AS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • Oliveira MA; Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • S S Quintans J; Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • Quintans Júnior LJ; Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • Scotti L; Universidade Federal da Paraíba, Paraíba, Brazil.
  • Scotti MT; Universidade Federal da Paraíba, Paraíba, Brazil.
  • da Silva Júnior EG; Regional University of Cariri, Ceará, Brazil.
  • Douglas Melo Coutinho H; Regional University of Cariri, Ceará, Brazil. Electronic address: hdmcoutinho@gmail.com.
  • Guimarães AG; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address: adrianagibara@hotmail.com.
Int J Pharm ; 662: 124538, 2024 Sep 05.
Article em En | MEDLINE | ID: mdl-39079594
ABSTRACT
Neuropathic pain is a high-intensity pain that can be caused by compression, transection, injury, nerve infiltration and drug treatment of cancer. Furthermore, drug therapy has low clinical efficacy, many adverse effects and remission of painful symptoms. In this way, natural products derived from plants constitute a promising therapeutic alternative. Therefore, the aim of this study was to evaluate the antihyperalgesic effect of γ-terpinene (γ-TPN) e γ-terpinene in ß-cyclodextrin inclusion complexes (TPN/CD) on neuropathic pain induced by tumor cells. Complexation extended the effect time for another 5 h and daily treatment for six days with γ-TPN (50 mg/kg, p.o.) and γ-TPN/ß-CD (50 mg/kg, p.o.) significantly reduced (p < 0.001) the mechanical hyperalgesia induced by the administration of 2x106 sarcoma cells 180 in the around the sciatic nerve. In addition, the Grip and Rota-rod techniques demonstrated that there was no interference on the muscle strength and motor coordination of the animals, suggesting that the compound under study does not have central nervous system depressant effects at the doses used. Molecular docking studies demonstrate favorable binding energies between γ-TPN and ß-CD, and alpha-2 adrenergic, glutamatergic, opioid and cholinergic receptors. Thus, this study demonstrates the potential of terpinene complexation in controlling neuropathic pain induced by tumor cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monoterpenos / Beta-Ciclodextrinas / Monoterpenos Cicloexânicos / Hiperalgesia / Neuralgia Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monoterpenos / Beta-Ciclodextrinas / Monoterpenos Cicloexânicos / Hiperalgesia / Neuralgia Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda