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Bacteria-Derived Cellulose Membranes Modified with Graphene Oxide-Silver Nanoparticles for Accelerating Wound Healing.
Luz, Erika Patrícia Chagas Gomes; da Silva, Thamyres Freire; Marques, Lidyane Souto Maciel; Andrade, Alexandre; Lorevice, Marcos Vinicius V; Andrade, Fabia Karine; Yang, Liu; de Souza Filho, Antonio Gomes; Faria, Andreia F; Silveira Vieira, Rodrigo.
Afiliação
  • Luz EPCG; Department of Chemical Engineering, Federal University of Ceará (UFC), Fortaleza, Ceará 60455-760, Brazil.
  • da Silva TF; Department of Chemical Engineering, Federal University of Ceará (UFC), Fortaleza, Ceará 60455-760, Brazil.
  • Marques LSM; Department of Chemical Engineering, Federal University of Ceará (UFC), Fortaleza, Ceará 60455-760, Brazil.
  • Andrade A; Department of Pathology and Forensic Medicine, Federal University of Ceará (UFC), Fortaleza, Ceará 60430-160, Brazil.
  • Lorevice MVV; Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo 13083-970, Brazil.
  • Andrade FK; Department of Chemical Engineering, Federal University of Ceará (UFC), Fortaleza, Ceará 60455-760, Brazil.
  • Yang L; Department of Environmental Engineering Sciences, University of Florida, Gainesville, Florida 32611-6540, United States.
  • de Souza Filho AG; Department of Physics, Federal University of Ceará (UFC), Bloco 922, Fortaleza, Ceará 60455-760, Brazil.
  • Faria AF; Department of Environmental Engineering Sciences, University of Florida, Gainesville, Florida 32611-6540, United States.
  • Silveira Vieira R; Department of Chemical Engineering, Federal University of Ceará (UFC), Fortaleza, Ceará 60455-760, Brazil.
ACS Appl Bio Mater ; 7(8): 5530-5540, 2024 Aug 19.
Article em En | MEDLINE | ID: mdl-39093994
ABSTRACT
This study reports on the modification of bacterial cellulose (BC) membranes produced by static fermentation of Komagataeibacter xylinus bacterial strains with graphene oxide-silver nanoparticles (GO-Ag) to yield skin wound dressings with improved antibacterial properties. The GO-Ag sheets were synthesized through chemical reduction with sodium citrate and were utilized to functionalize the BC membranes (BC/GO-Ag). The BC/GO-Ag composites were characterized to determine their surface charge, morphology, exudate absorption, antimicrobial activity, and cytotoxicity by using fibroblast cells. The antimicrobial activity of the wound dressings was assessed against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The results indicate that the BC/GO-Ag dressings can inhibit ∼70% of E. coli cells. Our findings also revealed that the porous BC/GO-Ag antimicrobial dressings can efficiently retain 94% of exudate absorption after exposure to simulated body fluid (SBF) for 24 h. These results suggest that the dressings could absorb excess exudate from the wound during clinical application, maintaining adequate moisture, and promoting the proliferation of epithelial cells. The BC/GO-Ag hybrid materials exhibited excellent mechanical flexibility and low cytotoxicity to fibroblast cells, making excellent wound dressings able to control bacterial infectious processes and promote the fast healing of dermal lesions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Staphylococcus aureus / Cicatrização / Materiais Biocompatíveis / Teste de Materiais / Testes de Sensibilidade Microbiana / Celulose / Escherichia coli / Nanopartículas Metálicas / Grafite Limite: Animals / Humans Idioma: En Revista: ACS Appl Bio Mater Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Staphylococcus aureus / Cicatrização / Materiais Biocompatíveis / Teste de Materiais / Testes de Sensibilidade Microbiana / Celulose / Escherichia coli / Nanopartículas Metálicas / Grafite Limite: Animals / Humans Idioma: En Revista: ACS Appl Bio Mater Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos