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Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 µg/kg) in Cats.
Fernandes, Naftáli S; Passos, Yanna D B; Arcoverde, Kathryn N; Mouta, Andressa N; Paiva, Thainá C; Oliveira, Kalyne D S; Araujo-Silva, Gabriel; de Paula, Valéria Veras.
Afiliação
  • Fernandes NS; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Passos YDB; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Arcoverde KN; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Mouta AN; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Paiva TC; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Oliveira KDS; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
  • Araujo-Silva G; Chemistry School, Amapá State University, Macapá 68900-070, AP, Brazil.
  • de Paula VV; Department of Animal Sciences, Semi-Arid Federal University, Mossoró 59625-900, RN, Brazil.
Animals (Basel) ; 14(15)2024 Aug 05.
Article em En | MEDLINE | ID: mdl-39123800
ABSTRACT
This study investigated the pharmacokinetic profile of and pharmacodynamic response to dexmedetomidine administered intramuscularly (IM) at a dose of 10 µg/kg in healthy cats. Nine adult cats were evaluated before and after administration of the drug, with serial collections of plasma samples. Dexmedetomidine induced deep sedation, with a rapid onset of action and a duration of one hour, reaching a peak between 20 and 30 min after administration. The half-life (T½) was 70.2 ± 48 min, with a maximum concentration (Cmax) of 2.2 ± 1.9 ng/mL and time to reach maximum concentration (Tmax) of 26.4 ± 19.8 min. The area under the curve (AUC) was 167.1 ± 149.1 ng/mL*min, with a volume of distribution (Vd) of 2159.9 ± 3237.8 mL/kg and clearance (Cl) of 25.8 ± 33.0 mL/min/kg. There was a reduction in heart rate (HR) and respiratory rate (RR) in relation to the baseline, with a slight decrease in systolic (SBP), diastolic (DBP), and mean (MAP) blood pressure in the first hour. Blood glucose increased after 60 min. Dexmedetomidine proved to be effective and safe, with rapid absorption, metabolization, and elimination, promoting good sedation with minimal adverse effects after IM administration in healthy cats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Animals (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Animals (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça