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Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve.
Lopes, Gele de Carvalho Araújo; Miranda, Brenda Caroline Rodrigues; Lima, João Orlando Piauilino Ferreira; Martins, Jorddam Almondes; de Sousa, Athanara Alves; Nobre, Taline Alves; Severo, Juliana Soares; da Silva, Tiago Eugênio Oliveira; Afonso, Milessa da Silva; Lima, Joana Darc Carola Correia; de Matos Neto, Emidio Marques; Torres, Lucillia Rabelo de Oliveira; Cintra, Dennys Esper; Lottenberg, Ana Maria; Seelaender, Marília; Silva, Moisés Tolentino Bento da; Torres-Leal, Francisco Leonardo.
Afiliação
  • Lopes GCA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • Miranda BCR; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • Lima JOPF; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • Martins JA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • de Sousa AA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • Nobre TA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • Severo JS; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
  • da Silva TEO; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 17012-900, SP, Brazil.
  • Afonso MDS; Department of Inflammation and Fibrosis, Gilead Sciences, Foster City, CA 94404, USA.
  • Lima JDCC; Cancer Metabolism Research Group, Department of Surgery and LIM26-HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo 17012-900, SP, Brazil.
  • de Matos Neto EM; Department of Physical Education, Federal University of Piauí, Teresina 64049-550, PI, Brazil.
  • Torres LRO; Federal Institute of Education, Science and Technology of Maranhão, Caxias 65030-005, MA, Brazil.
  • Cintra DE; Laboratory of Nutritional Genomics, University of Campinas, Campinas 13083-855, SP, Brazil.
  • Lottenberg AM; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences University of Campinas, São Paulo 13083-970, SP, Brazil.
  • Seelaender M; Hospital Israelita Albert Einstein (HIAE), São Paulo 05652-900, SP, Brazil.
  • Silva MTBD; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences University of Campinas, São Paulo 13083-970, SP, Brazil.
  • Torres-Leal FL; Hospital Israelita Albert Einstein (HIAE), São Paulo 05652-900, SP, Brazil.
Nutrients ; 16(15)2024 Jul 24.
Article em En | MEDLINE | ID: mdl-39125278
ABSTRACT
(1)

Background:

We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2)

Methods:

We assessed food intake, gastric retention (GR), and gene expression in all groups. (3)

Results:

Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4)

Conclusions:

This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Nervo Vago / Neuropeptídeo Y / Óleo de Soja / Óleo de Palmeira / Azeite de Oliva / Hipotálamo Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Nervo Vago / Neuropeptídeo Y / Óleo de Soja / Óleo de Palmeira / Azeite de Oliva / Hipotálamo Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça