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Challenges and trends in Gram-negative bacterial infections in critically neonates: A seven-and-a-half-year observational study.
Ferreira, Isadora Caixeta da Silveira; Machado, Izabella Clara de Brito; Menezes, Ralciane de Paula; Jesus, Thiago Alves de; Lopes, Mallu Santos Mendonça; Araújo, Lúcio Borges de; Ferreira, Daniela Marques de Lima Mota; Röder, Denise Von Dolinger de Brito.
Afiliação
  • Ferreira ICDS; Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Machado ICB; Undergraduate Course in Biomedicine, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Menezes RP; Technical Course in Clinical Analysis, Technical School of Health, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil. Electronic address: ralciane@ufu.br.
  • Jesus TA; Undergraduate Course in Biomedicine, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Lopes MSM; Undergraduate Course in Biomedicine, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Araújo LB; Faculty of Mathematics, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Ferreira DMLM; Neonatal Intensive Care Unit, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Röder DVDB; Department of Microbiology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Am J Infect Control ; 2024 Aug 09.
Article em En | MEDLINE | ID: mdl-39128485
ABSTRACT

BACKGROUND:

Analyze the incidence, risk factors, and fatality rates of bloodstream infections by Gram-negative bacteria (GNB-BSIs) in a Neonatal Intensive Care Unit.

METHODS:

This study employs a retrospective cohort design utilizing records of neonates admitted to the Neonatal Intensive Care Unit between January 2015 and June 2022.

RESULTS:

Among 1,495 neonates, 5.2% developed GNB-BSIs. The average incidence of infection per 1,000 patient-days was 2.9. Primary risk factors for infection that included preceeding carbapenem use were significant risk factors (odds ratio=514.4; P < .01) and fourth-generation cephalosporins (odds ratio=66; P < .01). Among the 85 GNB, 75.3% were fermenters, and 24.7% were non-fermenters. Of the isolates, 14.1% produced extended-spectrum beta-lactamase, and 2.3% carbapenem-resistant. Infection correlated with prolonged hospital stays (10-39days) and increased mortality (10%-29.9%).

CONCLUSIONS:

The high incidence of GNB-BSIs was exacerbated by the preceeding use of broad-spectrum antimicrobials, increasing the presence of multidrug-resistant isolates and fatality rates. These findings emphasize the importance of active surveillance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Infect Control Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Infect Control Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos