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Expanding the repertoire of ceDAF-12 ligands for modulation of the steroid endocrine system in C. elegans.
Galilea, Agustín; Santillán, Vanessa J; Acebedo, Sofía L; Dansey, María Virginia; Álvarez, Lautaro D; Mazaira, Gisela I; Galigniana, Mario D; Castro, Olga A; Gola, Gabriel F; Ramírez, Javier Alberto.
Afiliação
  • Galilea A; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Orgánica, ARGENTINA.
  • Santillán VJ; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Acebedo SL; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Dansey MV; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Álvarez LD; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Mazaira GI; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Galigniana MD; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Biológica, ARGENTINA.
  • Castro OA; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento FBMC, ARGENTINA.
  • Gola GF; University of Buenos Aires Faculty of Exact and Natural Sciences, Departamento de Química Orgánica, ARGENTINA.
  • Ramírez JA; Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Ciudad Universitaria, 3er piso, C1419EGA, Buenos Aires, ARGENTINA.
Chembiochem ; : e202400018, 2024 Aug 19.
Article em En | MEDLINE | ID: mdl-39159394
ABSTRACT
Steroid hormones are essential for the biological processes of eukaryotic organisms. The steroid endocrine system of C. elegans, which includes dafachronic acids (DA) and the nuclear receptor ceDAF-12, provides a simple model for exploring the role of steroid hormone signaling pathways in animals. In this study, we show for the first time the feasibility of designing synthetic steroids that can modulate different physiological processes, such as development, reproduction and ageing, in relation to ceDAF-12. Our results not only confirm the conclusions derived from genetic studies linking these processes but also provide new chemical tools to selectively manipulate them, as we found that different compounds produce different phenotypic results. The structures of these compounds are much more diverse than those of endogenous hormones and analogues previously described by other researchers, allowing further development of the chemical modulation of the steroid endocrine system in C. elegans and related nematodes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha