Brazilian report on primary immunodeficiencies in children: 166 cases studied over a follow-up time of 15 years.
J Clin Immunol
; 17(4): 340-5, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9258773
ABSTRACT
PIP: Over a 15-year observation period (1981-96), 166 cases of primary immunodeficiency disease (PID) were registered at the Department of Pediatrics, University of Sao Paulo, Brazil. PID was diagnosed according to World Health Organization criteria and only children with well-established deficiencies were included. The following frequencies were noted by PID classification: predominantly humoral defects (60.8%), T cell defects (4.9%), combined immunodeficiency (9.6%), phagocyte disorders (18.7%), and complement deficiencies (6%). The male to female ratio was 1.3 to 1. Immunoglobin A deficiency was the most frequent disorder (60 cases), followed by transient hypogammaglobulinemia (14 cases), chronic granulomatous disease (14 cases), and X-linked agammaglobulinemia (9 cases). Allergic symptoms occurred in 41% of cases. During the observation period, 23 children (13.8%) died, primarily of recurrent infections. Although improved diagnostic facilities have facilitated the recognition of immunodeficient children, the true incidence is likely to be higher than that detected in this study. Increased international collaboration is urged to improve the early detection of PID.
Palavras-chave
Age Factors; Americas; Biology; Brazil; Child; Child Health; Demographic Factors; Developing Countries; Health; Hematological Effects; Hemic System; Immunity; Immunoglobulin Alterations; Immunological Effects; Incidence; Latin America; Measurement; Physiology; Population; Population Characteristics; Research Methodology; Research Report; Retrospective Studies; South America; Studies; Youth
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes de Imunodeficiência
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Clin Immunol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda