Analysis of Mycobacterium avium complex serovars isolated from AIDS patients from southeast Brazil.
Mem Inst Oswaldo Cruz
; 92(4): 471-5, 1997.
Article
em En
| MEDLINE
| ID: mdl-9361739
ABSTRACT
PIP: Mycobacterium avium complex (MAC) organisms have been associated with severe opportunistic infections in patients with AIDS in the US. The present study analyzed the distribution of 90 MAC serovars isolated from 75 AIDS patients from Sao Paulo and Rio de Janeiro, Brazil, in 1990-94. 56 isolates (62.2%) showed a single serovar--predominantly serovars 8 (39.2%), 4 (21.4%), and 1 (10.7%). In the 34 isolates (37.8%) in which more than one serovar was identified, 19 (55.9%) were from a single site and 15 (44.1%) were isolated from different sites or from the same site but at different times. The most common serovars in mixed infections from both single and different sites were 8 (34.2% and 37%, respectively)) and 4 (21.1% and 25.9%, respectively). Only 11 isolates (12%) were M. intracellulare or M. scrofulaceum strains, indicating that M. avium was the opportunistic species in 88% of the MAC isolates in these Brazilian AIDS patients. Although the serovars detected in this series are similar to those found in US AIDS patients, the occurrence of mixed serovars was substantially higher in Brazilian AIDS patients. The clinical implications of polyclonal infections in Brazilian AIDS patients require further investigation, especially since serovars from distinct sites may have distinct drug resistance patterns.
Palavras-chave
Acquired Immunodeficiency Syndrome; Americas; Bacterial And Fungal Diseases; Biology; Brazil; Clinical Research; Developing Countries; Diseases; Hematological Effects; Hemic System; Hiv Infections; Infections; Latin America; Physiology; Research Methodology; Research Report; Signs And Symptoms; South America; Viral Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo Mycobacterium avium
/
Infecções Oportunistas Relacionadas com a AIDS
/
Infecções por Mycobacterium
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil