Modelling the risk of adult T-Cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I
Int J Cancer
; 43(2): 250-3, Feb. 1989.
Article
em En
| MedCarib
| ID: med-10007
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC261.A34
ABSTRACT
Adult T-cell leukemia/lymphoma (ATL), a malignancy of mature CD4-positive lymphocytes, has been etiologically linked to the human retrovirus HTLV-I. Although a long latent period is suggested from malignant studies, little prospective information on the risk of developing ATL among persons with HTLV-I infection is available. We present here a model of ATL risk based upon age- and sex-specific HTLV-I seroprevalence data from a cross-sectional survey of 13,000 Jamaicans and ATL incidence data from a 2« year case-control study. By examining the age-specific incidence of ATL relative to both adult and childhood-acquired seropositivity versus childhood-acquired seropositivity alone, we provide evidence in support of the hypothesis that childhood infection with HTLV-I is important to the development of ATL. Using this model, the cumulative lifetime risk of ATL for those infected before age 20 is estimated to be 4.0 percent for males and 4.2 percent for females. Under this hypothesis, HTLV-I-associated diseases with shorter latent periods, such as tropical spastic paraparesis, should have a higher incidence in adult females than in adult males. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Leucemia-Linfoma de Células T do Adulto
/
Modelos Biológicos
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1989
Tipo de documento:
Article