Insight, grey matter and cognitive function in first-onset psychosis
The British journal of psychiatry
; 197(2): 141-148, Aug. 2010. tab, graf
Article
em En
| MedCarib
| ID: med-17622
Biblioteca responsável:
TT5
Localização: TT5; W1, BR616
ABSTRACT
BACKGROUND:
Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures.AIMS:
Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.METHOD:
Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.RESULTS:
The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.CONCLUSIONS:
The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Esquizofrenia
/
Encefalopatias
/
Mapeamento Encefálico
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Imageamento por Ressonância Magnética
/
Cognição
Limite:
Adolescent
/
Adult
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Aged
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Female
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Humans
/
Male
Idioma:
En
Revista:
The British journal of psychiatry
Ano de publicação:
2010
Tipo de documento:
Article