Antibodies to extractable nuclear antigens: a comparative between SLE Patients in London and Jamaica - abstract
West Indian med. j
; 33(Suppl): 30, 1984.
Article
em En
| MedCarib
| ID: med-6082
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
In a study of 270 patients with SLE at the Hammersmith Hospital, London, the overall incidence of antibodies to extractable cellular antigens detected by DIE was 61 percent. In a series of 36 West Indian SLE patients, the comparable figure was 74 percent. Of particular interest was the fact that 50 percent of the Jamaican group had anti-RO, double the frequency of the London patients. Furthermore, there was an increased occurrence of anti-Sm antibodies demonstrated in 25 percent of sera of Jamaican cases as opposed to 7.5 percent. This divergence was even more striking when the British patients were assessed according to racial origin. Only 4 percent of Caucasians had anti-Sm, but 30 percent of the small population (10 percent) of Black and Chinese patients had the antibody. This data demonstrates the valuable role which the detection of anti-ENA plays in the serology of SLE. The presence of anti-Sm antibodies is now included in the revised criteria for the diagnosis of SLE, and it is thought that anti-Ro is associated with a sub-set of lupus patients who do not have anti-ds DNA antibodies (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Lúpus Eritematoso Sistêmico
Limite:
Humans
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1984
Tipo de documento:
Article
/
Congress and conference