Plasma haemoglobin and complement activation in sickle cell disease
J Clin Lab Immunol
; 6(1): 57-60, July 1981.
Article
em En
| MedCarib
| ID: med-9332
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
The role of haemolysis in producing deficient complement function in homozygous sickle cell disease was studied by measuring indices of complement activation and of haemolysis in 30 asymptomatic patients. Plasma concentration of C3d (an index of increased C3 turnover) was elevated in 40 percent of patients and modest decreases in serum concentration of C3 and functionally (haemolytically) active factor B were found. There was a positive correlation between C3d and plasma haemoglobin concentration (r = 0.56, p less than 0.005). Reticulocyte count and foetal haemoglobin concentration also contributed to variation in C3d, though to a lesser extent than plasma haemoglobin. Intravascular haemolysis in sickle cell disease may produce activation of complement and thus cause partial depletion of functional factor B and C3. This may reduce the immune function of the alternative pathway. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Traço Falciforme
/
Hemoglobinas
/
Ativação do Complemento
/
Anemia Falciforme
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Lab Immunol
Ano de publicação:
1981
Tipo de documento:
Article