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Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice
Goes, Annya Costa Araujo de Macedo; Pinto, Francisco Maxwell Martins; Fernandes, Guilherme Cardoso; Barbosa, Jessica Sales; Correia, Emanuela Santos; Ribeiro, Ronaldo Albuquerque; Guimaraes, Sergio Botelho; Lima Júnior, Roberto Cesar Pereira; Brito, Gerly Anne de Castro; Rodrigues, Lusmar Veras.
Afiliação
  • Goes, Annya Costa Araujo de Macedo; Federal University of Ceara (UFC). Department of Surgery. Postgraduate Program in Surgery. Fortaleza. Brazil
  • Pinto, Francisco Maxwell Martins; Federal University of Ceara (UFC). School of Pharmacy. Fortaleza. Brazil
  • Fernandes, Guilherme Cardoso; Federal University of Ceara (UFC). School of Pharmacy. Fortaleza. Brazil
  • Barbosa, Jessica Sales; Federal University of Ceara (UFC). School of Medicine. Fortaleza. Brazil
  • Correia, Emanuela Santos; Federal University of Ceara (UFC). Walter Cantidio Hospital. Fortaleza. Brazil
  • Ribeiro, Ronaldo Albuquerque; Federal University of Ceara (UFC). Department of Surgery. Postgraduate Program in Surgery. Fortaleza. Brazil
  • Guimaraes, Sergio Botelho; Federal University of Ceara (UFC). Department of Surgery. Experimental Surgical Research Laboratory (LABCEX). Fortaleza. Brazil
  • Lima Júnior, Roberto Cesar Pereira; Federal University of Ceara (UFC). Department of Pharmacology. Postgraduate Program in Pharmacology. Fortaleza. Brazil
  • Brito, Gerly Anne de Castro; Federal University of Ceara (UFC). Department of Morphology. Postgraduate Program in Morphology. Fortaleza. Brazil
  • Rodrigues, Lusmar Veras; Federal University of Ceara (UFC). Department of Surgery. Fortaleza. Brazil
Acta cir. bras. ; 29(12): 1-7, Dec. 2014. graf, tab, ilus
Article em En | VETINDEX | ID: vti-18918
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice.

METHODS:

Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated with EAc 100Hz and dexamethasone (DEXA) 1 mg/Kg/day, respectively. After three days, a colon segment was obtained for quantification of myeloperoxidase (MPO) activity, immunohistochemistry for iNOS, malondialdehyde (MDA) and cytokines (IL-1β and IL-10).

RESULTS:

Neutrophilic activity, assayed as MPO activity, was significantly higher in the TNBS colitis group than that in the saline control group. TNBS+EAc group showed suppression of IL-10 in the colon. EAc treatment significantly reduced the concentration of MDA and the expression of iNOS, as compared to the other groups.

CONCLUSION:

Electroacupuncture 100Hz applied to acupoint ST-36 promotes an anti-inflammatory action on the TNBS-induced colitis, mediated by increase of IL-10 and decrease of iNOS expression.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Trinitrobenzenos / Eletroacupuntura / Colite / Óxido Nítrico Sintase / Interleucina-10 Limite: Animals Idioma: En Revista: Acta cir. bras / Acta cir. bras. Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Trinitrobenzenos / Eletroacupuntura / Colite / Óxido Nítrico Sintase / Interleucina-10 Limite: Animals Idioma: En Revista: Acta cir. bras / Acta cir. bras. Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil