Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Acta cir. bras.
; 34(3): e201900305, Mar. 18, 2019. ilus, graf
Article
em En
| VETINDEX
| ID: vti-20872
Biblioteca responsável:
BR68.1
ABSTRACT
Purpose:
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).Methods:
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.Results:
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.Conclusion:
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Neoplasias Esofágicas
/
Adenocarcinoma
/
Usnea
/
Acetatos
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2019
Tipo de documento:
Article