Superoxid dismutase activity in portal vein endothelium after partial liver resection
Acta cir. bras.
; 28(9): 646-651, Sept. 2013. graf, tab
Article
em En
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| ID: vti-9040
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BR1.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To investigate superoxide dismutase (SOD) activity in the portal vein endothelium and malondialdehyde acid (MDA) production in liver tissue of rats submitted to 70% hepatectomy.METHODS:
Twelve rats were distributed in two groups (hepatectomy and sham). Animals were sacrificed on post operative day 1 and portal vein, liver tissue and blood samples were collected. Portal vein SOD production was measured using lucigenin-amplified chemiluminescence assays. MDA measurement was used as an index of oxidative stress through the formation of TBARS (Thiobarbituric Acid Reactive Species).RESULTS:
There was no difference in post operative bilirrubin, AST, ALT levels between groups. DHL level was higher in the hepatectomy group (p=0.01). MDA production in the remnant liver tissue and endothelial portal vein SOD activity were also significantly (p<0.05) elevated in the hepatectomy group when compared to control group. There was no correlation between MDA and SOD activity. SOD activity, on the other hand, showed a positive correlation with LDH level (p=0.038) and MDA levels showed a positive correlation with AST and ALT levels (p<0.001).CONCLUSION:
There is an increased production of malondialdehyde acid in liver tissue after partial hepatectomy and increased activity of superoxide dismutase in portal vein endothelium as well.(AU)Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Endotélio
/
Hepatectomia
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2013
Tipo de documento:
Article