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Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms
Saidi, Hadjer; Adi-Bessalem, Sonia; Hammoudi-Triki, Djelila; Laraba-Djebari, Fatima.
Afiliação
  • Saidi, Hadjer; University of Sciences and Technology Houari Boumedienne. Faculty of Biological Sciences. Alger. DZ
  • Adi-Bessalem, Sonia; University of Sciences and Technology Houari Boumedienne. Faculty of Biological Sciences. Alger. DZ
  • Hammoudi-Triki, Djelila; University of Sciences and Technology Houari Boumedienne. Faculty of Biological Sciences. Alger. DZ
  • Laraba-Djebari, Fatima; University of Sciences and Technology Houari Boumedienne. Faculty of Biological Sciences. Alger. DZ
J. venom. anim. toxins incl. trop. dis ; 19: 1-7, maio 2013.
Article em En | LILACS, VETINDEX | ID: biblio-1484528
Biblioteca responsável: BR1.1
Localização: BR68.1
ABSTRACT
Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector(Aah) and Androctonus amoreuxi (Aam). Results Comparison of the physiopathological effects induced by the two venoms showed differences in the kinetic of cytokine release and in lung injury. The lung edema was only observed in response to Aah venom and it was correlated with cell infiltration. In order to better understand the involved mechanism in inflammatory response, we used two antagonists, atropine (non-selective muscarinic antagonist) and propranolol (β adrenergic antagonist), which lead to a decrease of cell infiltration but has no effect on edema forming.Conclusion These results suggest another pathway in the development of lung injury following envenomation with Aam or Aah venom.
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Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Propranolol / Atropina / Venenos de Escorpião / Citocinas Limite: Animals Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. / J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argélia País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Propranolol / Atropina / Venenos de Escorpião / Citocinas Limite: Animals Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. / J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argélia País de publicação: Brasil