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BACKGROUND: Melasma is a chronic dermatosis that impacts the patient's quality of life and can present considerable challenges in terms of effective treatment. OBJECTIVE: To evaluate the effectiveness, tolerability, and safety of 5% cysteamine combined with 4% nicotinamide in female subjects with melasma. METHODS: This single-center, single-arm, prospective, open-label study evaluated patients with melasma using a combination cream of 5% cysteamine and 4% nicotinamide in a progressive regimen (60 min in the first month, 120 min in the second month, and 180 min in the third month). RESULTS: Overall, 35 treated subjects exhibited reduced modified Melasma Area and Severity Index (mMASI) (p < 0.001) and decreased MelasQoL scores (p < 0.001), accompanied by improved brightness, luminosity, homogeneity, and spot intensity (p < 0.001). Photographic and colorimetric analysis revealed smaller spots and improved homogeneity. LIMITATIONS: Adherence to progressive daily treatment could not be evaluated long-term. CONCLUSION: A combination cream comprising 5% cysteamine and 4% nicotinamide was effective, tolerable, and safe for treating melasma.
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Cisteamina , Combinação de Medicamentos , Melanose , Niacinamida , Índice de Gravidade de Doença , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Adulto Jovem , Administração Cutânea , Cisteamina/administração & dosagem , Cisteamina/efeitos adversos , Melanose/tratamento farmacológico , Melanose/diagnóstico , Niacinamida/administração & dosagem , Niacinamida/efeitos adversos , Estudos Prospectivos , Qualidade de Vida , Creme para a Pele/administração & dosagem , Creme para a Pele/efeitos adversos , Resultado do TratamentoRESUMO
BACKGROUND: Here, we investigated the impact of IFN-lambda-3 polymorphism on specific IgG responses for COVID-19 in older adults seropositive for CMV. METHODS: Blood samples of 25 older adults of both sexes were obtained at three different times: during a micro-outbreak (MO) of SARS-CoV-2 in 2020; eight months after (CURE); and 30 days after the administration of the second dose of ChadOx-1 vaccine (VAC). The specific IgG for both SARS-CoV-2 and CMV antigens, neutralizing antibodies against SARS-CoV-2, and also the polymorphism profile for IFN-lambda-3 (rs12979860 C > T) were assessed. RESULTS: Higher levels of specific IgG for SARS-CoV-2 antigens were found in the MO and VAC than in the CURE time-point. Volunteers with specific neutralizing antibodies against SARS-CoV-2 showed better specific IgG responses for SARS-CoV-2 and lower specific IgG levels for CMV than volunteers without specific neutralizing antibodies. Significant negative correlations between the specific IgG levels for SARS-CoV-2 and CMV were found at the MO time-point, as well as in the group of individuals homozygous for allele 1 (C/C) in the MO time-point and heterozygotes (C/T) in the CURE time-point. CONCLUSION: Our results suggested that both CMV seropositivity and the homozygosis for allele 1 (C/C) in IFN-lambda-3 gene can negatively impact the antibody response to COVID-19 infection and vaccination in older adults.
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Resumo Introdução A terapia ocupacional é uma profissão com mais visibilidade histórica na área da saúde. No âmbito da política pública da assistência social, sua inserção passou a ser oficialmente prevista a partir de 2011, embora atue neste setor desde o início de suas ações no Brasil. Objetivo Neste estudo, objetivou-se traçar o perfil dos terapeutas ocupacionais inseridos nos serviços e/ou programas do Sistema Único de Assistência Social (SUAS) no estado de Minas Gerais (MG). Método Realizou-se pesquisa documental, tendo como fonte de informações o Censo SUAS. Foram mapeados os dados quantitativos de municípios com terapeutas ocupacionais por ano, por equipamentos, serviços e função entre os anos de 2012 e 2019. Os dados foram tratados por meio de estatística simples e os resultados foram organizados em categorias analíticas, as quais integraram a discussão dos resultados. Resultados Foram encontrados dados dos terapeutas ocupacionais em equipamentos do SUAS da Proteção Social Básica e da Proteção Social Especial e no nível da gestão. Destacou-se quantitativo relevante de terapeutas ocupacionais em serviços para pessoas com deficiência. Conclusão A constituição da terapia ocupacional social, o reconhecimento da especialização da profissão em contextos sociais e a previsão deste profissional no SUAS tem ampliado o debate e as possibilidades de atuação com foco na proteção social. Sugere-se outros estudos acerca do perfil desses profissionais, bem como das práticas desenvolvidas por eles visando compreender suas atuações, aplicação dos conhecimentos teórico-práticos e contribuição da especificidade da terapia ocupacional neste contexto.
Abstract Introduction Occupational therapy is the profession with more historical visibility related to the health field. Within the scope of the public policy of social assistance, its insertion started to be officially foreseen from 2011, however its action has been developed in the beginning of occupational therapists' action in Brazil. Objective To present the profile of occupational therapists inserted in the services and/or programs of the Unified Social Assistance System (SUAS) in Minas Gerais (MG) state, Brazil. Method Documentary research was carried out, using the SUAS Census as a source of information. Quantitative data from municipalities with occupational therapists per year, by equipment, services, and role between the years 2012 to 2019 were mapped. The data were treated using simple statistics, and the results were organized into analytical categories, which were part of the discussion of the results. Results Data from occupational therapists were found in SUAS equipment for Basic Social Protection, Special Social Protection, and at the management level. A relevant number of occupational therapists in services for people with disabilities stood out. Conclusion The constitution of social occupational therapy, the recognition of the profession's specialization in social contexts, and the provision of this professional in the SUAS has expanded the debate and the possibilities of action with a focus on social protection. Other studies are suggested about the professionals' profile, as well as the practices developed by them, aiming to understand their actions, application of theoretical-practical knowledge and contribution of the specificity of occupational therapy in this context.
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Introdução: O câncer de mama é a neoplasia mais frequente entre as mulheres. Com a evolução dos tratamentos disponíveis, houve um aumento da sobrevida das pessoas com diagnóstico de câncer de mama. Contudo, a maior sobrevida quase sempre é acompanhada de comorbidades físicas e ou psicológicas que podem impactar na qualidade de vida destas mulheres. Objetivo: Avaliar a qualidade de vida de mulheres com câncer de mama que foram submetidas a tratamento por meio de intervenção cirúrgica. Material e métodos: Participaram do estudo 87 mulheres diagnosticadas com câncer de mama e que foram submetidas í intervenção cirúrgica. A qualidade de vida foi avaliada pelo questionário QLQ-C30 e QLQ-BR23. A análise estatística descritiva foi realizada no software GraphPad Prism v.5. Resultados: No QLQ-C30 foram observados bons níveis de qualidade de vida, entretanto no QLQ-BR23, questionário específico para o câncer de mama, observou-se que a qualidade de vida desses indivíduos estava prejudicada. Conclusão: Os resultados demonstram que a qualidade de vida de pacientes que passaram por tratamento cirúrgico de câncer de mama está comprometida. Deste modo, é necessário que as equipes multidisciplinares de saúde ajam na tentativa de promover a saúde e a qualidade de vida destas pessoas. (AU)
Introduction: Breast cancer is the most common neoplasm among women. With the evolution of available treatments, the life expectancy of people diagnosed with breast cancer increased. However, the greater survival is almost always accompanied by physical and/or psychological comorbidities that may impact the quality of life. Objective: To evaluate the quality of life of women with breast cancer submitted to treatment by means of surgical intervention. Methods: Thirty-eight women diagnosed with breast cancer participated in the study and underwent surgical intervention. Quality of life was assessed using the QLQ-C30 and QLQ-BR23 questionnaires. The descriptive statistical analysis was performed in GraphPad Prism v.5 software. Results: Good quality of life was observed in the QLQ-C30; however, in QLQ-BR23, a specific questionnaire for breast cancer, it was observed that the quality of life of these individuals was impaired. Conclusion: The results demonstrate that the quality of life of patients who undergo surgical treatment of breast cancer is compromised. Thus, it is necessary to promote the health and quality of life of these patients with multidisciplinary health teams. (AU)
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Humanos , Feminino , Qualidade de Vida , Neoplasias da Mama , MastectomiaRESUMO
A geração de conhecimento obtida por meio da pesquisa científica materializa-se no anúncio dos resultados à sociedade. Este se faz basicamente de 2 formas: com apresentações em congressos e publicação de artigos científicos, ou por meio da solicitação de patentes. Se há intenção em auferir ganhos financeiros e materiais com as descobertas, ideias e inventos resultantes da pesquisa, a solicitação de uma patente se faz necessária. O objetivo deste artigo foi contribuir com a divulgação das informações pertinentes às patentes para o profissional da Odontologia brasileira. Uma descrição sucinta das etapas necessárias para a sua solicitação foi realizada. Deve-se reconhecer o esforço do Instituto Nacional de Propriedade Industrial (INPI) em disponibilizar no seu sítio eletrônico todas as informações necessárias aos interessados em fazer um pedido de patente, de maneira inteligível e didática, possibilitando a estes realizar seus próprios pedidos de patente de maneira autônoma.
The generation of knowledge obtained through scientific research materializes in the announcement of results to society. This is basically done in two ways: with presentations at congresses and publication of scientific articles, or through the application for patents. If there is an intention to make financial and material gains with the discoveries, ideas and inventions resulting from the research, the application for a patent is necessary. The aim of this article was to contribute to the dissemination of information pertinent to patents for the Brazilian Dentistry professional. A brief description of the steps required for its request has been made. It must be recognized the effort of the Instituto Nacional da Propriedade Industrial (INPI) to make available on its website all the information necessary to those interested in making a patent application, in an intelligible and didactic way, enabling them to make their own patent applications.
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Patente , Odontologia , Tecnologia Odontológica , Propriedade Intelectual , InvençõesRESUMO
Oil sludge or waste generated in transport, storage or refining forms highly stable mixtures due to the presence and additives with surfactant properties and water forming complex emulsions. Thus, demulsification is necessary to separate this residual oil from the aqueous phase for oil processing and water treatment/disposal. Most used chemical demulsifiers, although effective, are environmental contaminants and do not meet the desired levels of biodegradation. We investigated the application of microbial biosurfactants as potential natural demulsifiers of petroleum derivatives in water emulsions. Biosurfactants crude extracts, produced by yeasts (Candida guilliermondii, Candida lipolytica and Candida sphaerica) and bacteria (Pseudomonas aeruginosa, Pseudomonas cepacia and Bacillus sp.) grown in industrial residues, were tested for demulsification capacity in their crude and pure forms. The best results obtained were for bacterial biosurfactants, which were able to recover about 65% of the seawater emulsified with motor oil compared to 35-40% only for yeasts products. Biosurfactants were also tested with oil-in-water (O/W) and water-in-oil (W/O) kerosene model emulsions. No relationship between interfacial tension, cell hydrophobicity and demulsification ratios was observed with all the biosurfactants tested. Microscopic illustrations of the emulsions in the presence of the biosurfactants showed the aspects of the emulsion and demulsification process. The results obtained demonstrate the potential of these agents as demulsifiers in marine environments.
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A tomografia computadorizada desempenha um papel importante no diagnóstico de anomalias e condições patológicas da ATM, permitindo a visualização completa da região articular, fornecendo um diagnóstico mais preciso. Para avaliação das imagens tomográficas é necessário que o profissional tenha o conhecimento da anatomia seccional da região articular, para que o mesmo reconheça as alterações estruturais. Assim, foi exposto e descrito neste trabalho as características tomográficas de normalidade, alterações morfológicas e condições patológicas mais encontradas na região da articulação temporomandibular. Sendo a tomografia computadorizada um exame de imagem superior aos métodos convencionais de imagem para ATM, pois permite uma visualização tridimensional adequada e apurada de todos os detalhes ósseos sem a limitação das sobreposições, fornecendo o tamanho e formato real das estruturas anatômicas, alterações morfológicas e condições patológicas.
The computed tomography plays an important role in the diagnosis of anomalies and pathological conditions of the TMJ, providing a complete visualization of joint region, providing a more accurate diagnosis. For evaluation of the images is necessary to the professional the knowledge of sectional anatomy of the joint region, so he can recognize the structural changes. Therefore, it was explained and described in this study the characteristics of normal CT, morphological and pathological conditions commonly found in the region of the temporomandibular joint. The Computed tomography is an imaging exam superior than the conventional imaging exam for TMJ, because it allows an adequate and accurate three-dimensional visualization of all details of the bone, without the limitation of overlap, providing the real size and shape of the anatomical structures, morphological changes and pathological conditions.
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Crianças pré-termo podem apresentar distúrbios leves do desenvolvimento motor, que podem ser imperceptíveis até a idade pré-escolar ou escolar. O objetivo desse estudo foi comparar o desenvolvimento motor de crianças pré-termo moderadas com crianças a termo aos sete e oito anos de idade. Foram coletados dados de 13 crianças pré-termo e 13 crianças a termo de uma escola da rede municipal de Betim. Foi utilizada a Escala de Desenvolvimento Motor para avaliar motricidade fina, motricidade global, equilíbrio, esquema corporal, organização espacial e organização temporal, bem como a idade motora geral e o quociente motor geral. O teste Mann-Whitney foi utilizado para comparar as idades motoras e os quocientes motores entre os grupos. Foi encontrada diferença significativa somente nos valores da motricidade fina entre os grupos (p=0,01), sendo que o grupo pré-termo apresentou desempenho inferior. Dessa forma, crianças pré-termo moderadas que não apresentam características de alto risco biológico ao nascimento também podem necessitar de acompanhamento ambulatorial até a idade escolar.
Preterm children may have light motor developmental impairments, which may be imperceptible until pre-school age or even school age. The aim of this study was to compare the motor development of moderate preterm children with full-term ones at seven and eight years of age. Data from 13 preterm and 13 full-term children were collected from a public school in Betim-MG. The Motor Development Scale was used to access fine and global motricity, balance, body scheme, spatial organization, time organization, as well as general motor age and general motor quotient. The Mann-Whitney's Test was used to compare the motor ages and motor quotients between the groups. A significant difference was only found in the fine motricity values between the groups (p=0.01), the preterm group having shown a poorer performance. Therefore, moderate preterm children who do not have highly risky biological characteristics at birth may also need outpatient assistance up to school age.
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Humanos , Masculino , Feminino , Criança , Aptidão , Desenvolvimento Infantil , Recém-Nascido Prematuro , Destreza MotoraRESUMO
OBJECTIVE: This study reviews our experience with laparoscopic cholecystectomy in the treatment of cholelithiasis in transplant patients. METHODS: Demographic data, medications used, and operative and postoperative data of all transplant recipients who were subjected to laparoscopic cholecystectomy for cholelithiasis at our hospital were obtained. RESULTS: A total of 15 transplant patients (13 renal transplantation and 2 bone marrow transplantation) underwent laparoscopic cholecystectomy. All patients were admitted to the hospital on the day of the operation. The immunosuppressive regimen was not modified during hospitalization. Clinical presentation of cholelithiasis was biliary colicky (n=12), acute cholecystitis (n=2), and jaundice (n=1). The operation was uneventful in all patients. Postoperative complications were nausea and vomiting in 2 patients, prolonged tracheal intubation in 1, wound infection in 1 and large superficial hematoma in 1 patient. CONCLUSION: Laparoscopic cholecystectomy is associated to a low morbidity and mortality and good postoperative outcome in transplant patients with uncomplicated cholecystitis.
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Transplante de Medula Óssea , Colecistectomia Laparoscópica , Colelitíase/cirurgia , Transplante de Rim , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
BACKGROUND: Mesenteric thrombosis related to trauma is an uncommon entity and has poor prognosis when have low flow and hemorrhagic shock. It usually presents with a challenging diagnosis and high mortality rates, despite appropriate treatment. CASE REPORT: Patient with blunt trauma was admitted and initial treatment, complementary exams showed ribs and humerus fractures. Computerized tomography showed aerial distension in small bowels along with gastric stasis and hidropneumothorax. The patient had hypotension during clinical observation and cardiopulmonary arrest, responding to reanimation. Taken to surgery for damage control, it was found extensive necrosis of right colon, which was excised and performed primary anastomosis. He was admitted in the intensive care unit, evolving with oliguria, miosis, convulsion, and pulseless electric activity, dying three days after hospital admission. CONCLUSION: Although uncommon, mesenteric ischemia with venous thrombosis might be secondary to systemic hypotension, frequently followed by fatal outcomes.
INTRODUÇÃO: Trombose mesentérica, relacionada a trauma é entidade incomum, com pobre prognóstico quando seguida de estados de baixo fluxo e choque hipovolêmico. Geralmente apresenta-se com quadro de difícil diagnóstico, cuja mortalidade é elevada a despeito de tratamento adequado. RELATO DO CASO: Paciente submetido a trauma, após admissão hospitalar e atendimento inicial, exames radiológicos demonstraram fratura de costela e úmero. Tomografia computadorizada evidenciou distensão aérea em intestino delgado associada à estase gástrica e hidropneumotórax. O paciente evoluiu com hipotensão durante o período de observação clínica e parada cardiorrespiratória que respondeu à reanimação. Levado para operação para controle de danos, encontrou-se extensa necrose de cólon ascendente. Realizou-se hemicolectomia direita com íleotransversostomia. Levado à unidade de terapia intensiva, evoluiu com oligúria, miose, convulsão e atividade elétrica sem pulso, falecendo três dias após dar entrada no hospital. CONCLUSÃO: Embora incomum, isquemia mesentérica com trombose venosa pode ser secundária à hipotensão sistêmica, com desfecho fatal.