1.
In. II International Congress on Neuroregeneration. Proceedings (selected papers). Rio de Janeiro, UFRJ, 2004. p.113-126, ilus, graf.
Monografia
em Inglês
| LILACS
| ID: lil-682600
RESUMO
This review discusses present understanding of the role of apoptosis and signaling cascades in neuronal pathogenesis and survival. It focuses on a herpes simplex virus type 2 (HSV-2) gene, known as ICP10PK, that prevents cell death/apoptosis in a wide spectrum of neurodegenerative conditions. Therapeutic implications for the development of HSV vectors that deliver ICP10PK and their use in the treatment/prevention of neurodegenerative disease are discussed.